426819-22-9

Upstream product

• 426819-08-1 3-acetyl-5-(2'-O-acetyl-3'-amino-3'-deoxy-α-L-threofuranosyl)-2-methylpyrrole 
• 426819-14-9 4-(2'-O-acetyl-3'-deoxy-3'-isothiocyanato-α-L-threofuranosyl)-1,3-dihydro-3-methyl-1-p-tolyl-2H-imidazole-2-thione 
• 426818-85-1 4-(3'-azido-3'-deoxy-α-L-threofuranosyl)-1,3-dihydro-3-methyl-1-p-tolyl-2H-imidazole-2-thione 
• 426818-69-1 1,3-dihydro-3-methyl-4-(2',3'-O-sulfonyl-β-D-erythrofuranosyl)-1-p-tolyl-2H-imidazole-2-thione 
• 426819-06-9 4-(2'-O-acetyl-3'-amino-3'-deoxy-α-L-threofuranosyl)-1,3-dihydro-3-methyl-1-p-tolyl-2H-imidazole-2-thione 
• 426818-98-6 4-(2'-O-acetyl-3'-azido-3'-deoxy-α-L-threofuranosyl)-1,3-dihydro-3-methyl-1-p-tolyl-2H-imidazole-2-thione 

Relevant academic research and scientific papers

Fluoronucleosides, isothiocyanato C-nucleosides, and thioureylene di-C-nucleosides via cyclic sulfates

Cyclic sulfates of N- and C-nucleosides (D-ribo and D-erythro configurations, respectively) are used to prepare 3′-fluoro and 3′-azido D-Xylo N-nucleosides and L-threo C-nucleosides. The reduction of the 3′-azido C-nucleosides (furan, imidazoline-2-thione, and pyrrole derivatives) gives 3′-amino C-nucleosides, which, by reaction with thiocarbonyldiimidazole, are transformed into 3′-isothiocyanato C-nucleosides. Reaction of the 3′-amino with the 3′-isothiocyanato C-nucleosides gives thioureylene di-C-nucleosides, a type of nucleotide analogue with a nonionic bridge isosteric of the phosphate group.