426820-09-9

Basic information

• Product Name: 1-(4-ethyl-benzenesulfonyl)-2-tridecyl-4-trityl-piperazine
• Synonyms: 1-(4-ethyl-benzenesulfonyl)-2-tridecyl-4-trityl-piperazine
• CAS NO: 426820-09-9
• Molecular Weight: 679.023
• Mol File: 426820-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-ethyl-benzenesulfonyl)-2-tridecyl-4-trityl-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ethyl-benzenesulfonyl)-2-tridecyl-4-trityl-piperazine(426820-09-9)
• EPA Substance Registry System: 1-(4-ethyl-benzenesulfonyl)-2-tridecyl-4-trityl-piperazine(426820-09-9)

Safety Data

• Hazardous Substances Data: 426820-09-9(Hazardous Substances Data)

Upstream product

• 98-69-1 p-ethylbenzenesulfonic acid 
• 76-83-5 trityl chloride 

Relevant articles and documents

Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A2 inhibition: Syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines

1-Benzoyl-2-alkyl piperazines are strong inhibitors of Group I and II secreted PLA2s. An improvement of their activity was obtained by replacing the amide function by a sulfamide and by introduction of electrodonor substituents on the para position of the benzenesulfonyl moiety. Neither the position on one of the carbon of the piperazine ring nor the absolute configuration of this carbon have an effect on the affinity for one or the other group of PLA2, but the lipophilicity remains for these series an essential parameter. In addition structure-activity relationships allow new hypothesis on interaction of these piperazine derivatives with the catalytic site of PLA2s.