426824-19-3

Upstream product

• 56686-56-7 3,5,5,5-tetrachloro-2-pentanone 
• 126-81-8 dimedone 

Downstream Products

• 426823-95-2 1-(3-fluoro-phenyl)-2,6,6-trimethyl-3-(2,2,2-trichloro-ethyl)-1,5,6,7-tetrahydro-indol-4-one 
• 426823-94-1 1-(2,4-difluoro-phenyl)-2,6,6-trimethyl-3-(2,2,2-trichloro-ethyl)-1,5,6,7-tetrahydro-indol-4-one 
• 426823-91-8 2,6,6-trimethyl-1-(4-nitro-phenyl)-3-(2,2,2-trichloro-ethyl)-1,5,6,7-tetrahydro-indol-4-one 
• 426823-97-4 1-butyl-2,6,6-trimethyl-3-(2,2,2-trichloro-ethyl)-1,5,6,7-tetrahydro-indol-4-one 
• 426823-89-4 3-(2,2,2-trichloroethyl)-2,6,6-trimethyl-1-(4-methyl-3-chlorophenyl)-4,5,6,7-tetrahydro-1H-indol-4-one 
• 426823-93-0 2,6,6-trimethyl-1-(2-methyl-5-nitro-phenyl)-3-(2,2,2-trichloro-ethyl)-1,5,6,7-tetrahydro-indol-4-one 
• 426823-96-3 1-(2-chloro-5-trifluoromethyl-phenyl)-2,6,6-trimethyl-3-(2,2,2-trichloro-ethyl)-1,5,6,7-tetrahydro-indol-4-one 
• 121625-71-6 1-n-butyl-2,6,6'-trimethyl-4-oxo-4,5,6,7-tetrahydro-3-indole acetic acid 

Relevant academic research and scientific papers

A new method for the synthesis of N-substituted (4-oxo-4,5,6,7-tetrahydroindol-3-yl)acetic acids

A new method for the synthesis of N-substituted 2-(4-oxo-4,5,6,7-tetrahydroindol-3-yl)acetic acids was developed. Alkylation of cyclic 1,3-diketones with 3,5,5,5-tetrachloropentan-2-one affords 1,4-diketones, which undergo cyclization with different primary amines into N-substituted 3-(2,2,2-trichloroethyl)-4,5,6,7-tetrahydroindol-4-ones. Acid hydrolysis of the latter gives the corresponding indol-3-ylacetic acids. The structures of the compounds obtained were confirmed by 1H and 13C NMR data.