426842-85-5Relevant articles and documents
Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics
Flagstad, Thomas,Petersen, Mette T.,Hinnerfeldt, Daniel M.,Givskov, Michael,Nielsen, Thomas E.
, p. 3263 - 3267 (2014)
A practical and scalable 4-step route is presented for the synthesis of 4-bromo-3-fluoro-6-methoxyoquinoline and 3-fluoro-4-iodo-6-methoxyoquinoline from readily available 2,4-dichloro-3-fluoroquinoline with an overall yield of 81-85%. Halogenated quinoline building blocks have found much use in antimicrobial drug discovery, and the method reported here would be useful for the synthesis of these compounds.
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid
Sch?fer, Gabriel,Fleischer, Tony,Blumer, Nicole,Udry, Megan,Reber, Stefan,Stansfield, Ian,Liu, Yuanhua,Li, Yan,Li, Pixu
, p. 347 - 357 (2022/02/01)
A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C-F bond via a Balz-Schiemann reaction or electrophilic fluorinatio
Hepatitis C Virus Inhibitors
-
, (2013/05/21)
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.