426844-70-4Relevant academic research and scientific papers
Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Fukushima, Hiroshi,Hiratate, Akira,Takahashi, Masato,Saito-Hori, Masako,Munetomo, Eiji,Kitano, Kiyokazu,Saito, Hidetaka,Takaoka, Yuji,Yamamoto, Koji
experimental part, p. 1110 - 1117 (2009/10/02)
Dipeptidyl peptidase IV (DPP-IV) inhibitors have attracted attention as potential drugs for use in the treatment of type 2 diabetes because they prevent the degradation of glucagon-like peptide-1 (GLP-1) and extend its duration of action. We previously reported that 2-cyano-4-fluoropyrrolidines act as potent DPP-IV inhibitors and have been modifying the 1-position of pyrrolidine to obtain more useful inhibitors. An L-tert-butylglycine derivative was found to be a stable and potent DPP-IV inhibitor that exhibits a glucose lowering effect in vivo. Here, we report the synthesis of and biological data on the aforementioned derivatives.
