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Benzenepropanoic acid, α-fluoro-β-hydroxy-β-phenyl, ethyl ester, also known as Fenoprofen, is a nonsteroidal anti-inflammatory drug (NSAID) with both analgesic and antipyretic properties. It is chemically classified as a propionic acid derivative, with the molecular formula C15H14FO2. Fenoprofen is used to relieve pain, inflammation, and fever, and is commonly prescribed for conditions such as arthritis, ankylosing spondylitis, and dysmenorrhea. The drug works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins that cause inflammation and pain. As an ethyl ester, Fenoprofen is rapidly hydrolyzed in the body to its active form, allowing for effective pain relief and inflammation reduction. However, it is important to note that, like other NSAIDs, Fenoprofen may cause side effects such as gastrointestinal issues, kidney problems, and increased risk of cardiovascular events, and should be used with caution, especially in patients with a history of these conditions.

427-31-6

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427-31-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 427-31-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,2 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 427-31:
(5*4)+(4*2)+(3*7)+(2*3)+(1*1)=56
56 % 10 = 6
So 427-31-6 is a valid CAS Registry Number.

427-31-6Downstream Products

427-31-6Relevant academic research and scientific papers

Catalyst free synthesis of α-fluoro-β-hydroxy ketones/α-fluoro-ynols via electrophilic fluorination of tertiary propargyl alcohols using Selectfluor (F-TEDA-BF4)

Naveen, Naganaboina,Balamurugan, Rengarajan

, p. 2063 - 2072 (2017)

A facile method for the synthesis of α-fluoro-β-hydroxy ketones/α-fluoro-ynols from tertiary propargyl alcohols under electrophilic fluorination conditions using F-TEDA-BF4 has been presented. The products bear pharmaceutically important α-fluoro ketone, gem-diaryl and fluorohydrin moieties in the same molecule. Interestingly, this catalyst free protocol results in monofluorination.

Catalyzed reformatsky reactions with ethyl bromofluoroacetate for the synthesis of α-fluoro-β-hydroxy acids

Ocampo,Dolbier, Jr.,Abboud,Zuluaga

, p. 72 - 78 (2007/10/03)

The presence of catalytic amounts of CeCl3 improves yields and simplifies procedure in the Reformatsky reactions of ethyl bromofluoroacetate with aldehydes and ketones to generate diastereomeric mixtures of α-fluoro-β-hydroxy esters, some of which can be separated by crystallization or column flash chromatography. Diastereomerically pure α-fluoro-β-hydroxy acids are obtained by mild alkaline hydrolysis of the resolved α-fluoro-β-hydroxy esters. Detailed NMR data of new α-fluoro-β-hydroxy esters and α-fluoro-β-hydroxy acids are also presented.

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