427-40-7

Basic information

• Product Name: 4-Piperidinemethanol, a-(4-fluorophenyl)-a-phenyl-
• CAS NO: 427-40-7
• Molecular Formula: C18H20FNO
• Molecular Weight: 285.361
• Mol File: 427-40-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-Piperidinemethanol, a-(4-fluorophenyl)-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinemethanol, a-(4-fluorophenyl)-a-phenyl-(427-40-7)
• EPA Substance Registry System: 4-Piperidinemethanol, a-(4-fluorophenyl)-a-phenyl-(427-40-7)

Safety Data

• Hazardous Substances Data: 427-40-7(Hazardous Substances Data)

Upstream product

• 25519-80-6 4-(benzoyl)piperidine hydrochloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 25519-79-3 1-(4-benzoylpiperidin-1-yl)ethanone 
• 58113-20-5 1-acetyl-α-(4-fluorophenyl)-α-phenyl-4-piperidinemethanol 

Downstream Products

• 1383479-19-3 C₂₇H₃₀FN₃O₃S₂ 
• 60284-74-4 1-[3-(p-acetyl-o-methoxyphenoxy) propyl]-4-(α-p-fluorophenyl-α-hydroxy)benzylpiperidine 

Relevant articles and documents

Synthesis and SAR of selective small molecule neuropeptide y Y2 receptor antagonists

Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16 (CYM 9484) and 54 (CYM 9552) with IC50 values of 19 nM and 12 nM respectively.

4-[(diaryl)hydromethyl]-1-piperidinealkanols and esters and carbamates thereof useful in the treatment of allergic disorders

Novel compounds of the formula: STR1 are disclosed wherein Ar and Ar1 are phenyl, sustituted phenyl or pyridinyl, "alk" is a C1 -C12 straight or branched hydrocarbon chain, and R is H, loweralkylcarbonyl, arylcarbonyl, or aminocarbonyl where the amino is unsubstituted or substituted by one or two groups selected from loweralkyl or aryl. The compounds of this invention are useful in the treatment of allergic disorders.

Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment

A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.