42753-67-3

Basic information

• Product Name: CHEMPACIFIC 38169
• Synonyms: CHEMPACIFIC 38169;3-ETHYL-PYRIDIN-2-YLAMINE;2-AMINO-3-ETHYL-PYRIDINE;3-ETHYLPYRIDIN-2-AMINE;2-Pyridinamine, 3-ethyl-;3-Ethyl-2-pyridinaMine;EOS-61816
• CAS NO: 42753-67-3
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 42753-67-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 236℃
• Flash Point: 119℃
• Appearance: /
• Density: 1.037
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.19±0.36(Predicted)
• CAS DataBase Reference: CHEMPACIFIC 38169(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMPACIFIC 38169(42753-67-3)
• EPA Substance Registry System: CHEMPACIFIC 38169(42753-67-3)

Safety Data

• Hazardous Substances Data: 42753-67-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 42753-67-3 differently. You can refer to the following data:
1. As a pyridine derivative, 3-Ethyl-2-pyridinaMine can be used in the preparation of glutaramides as potential inhibitors of neutral endopeptidase.
2. A pyridine derivative used in the preparation of glutaramides as potential inhibitors of neutral endopeptidase.

InChI:InChI=1S/C7H10N2/c1-2-6-4-3-5-9-7(6)8/h3-5H,2H2,1H3,(H2,8,9)

Upstream product

• 110-86-1 pyridine 
• 14906-62-8 3-ethylpyridine N-oxide 
• 407-25-0 trifluoroacetic anhydride 
• 52200-48-3 3-bromo-2-chloropyridine 
• 54230-88-5 8-bromotetrazolo[1,5-a]pyridine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 557-20-0 diethylzinc 
• 138343-75-6 tert-butyl (3-methylpyridin-2-yl)carbamate 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 54231-32-2 3-chloro-2-nitropyridine 
• 844503-09-9 3-ethenyl-2-nitropyridine 
• 149489-03-2 tert-butyl (3-ethylpyridin-2-yl)carbamate 
• 271-63-6 7-Azaindole 
• 536-78-7 3-ethylpyridine 

Downstream Products

• 906069-76-9 2-[1-(3-ethyl-pyridin-2-ylcarbamoyl)-cyclopentylmethyl]-pentanoic acid benzyl ester 
• 96440-05-0 2-chloro-3-ethylpyridine 
• 1037253-14-7 5-bromo-3-ethylpyridin-2-amine 

Relevant articles and documents

Mild, General, and Regioselective Synthesis of 2-Aminopyridines from Pyridine N -Oxides via N -(2-Pyridyl)pyridinium Salts

A synthesis of 2-aminopyridines from pyridine N-oxides via their corresponding N-(2-pyridyl)pyridinium salts has been demonstrated and investigated. The reaction sequence features a highly regioselective conversion of the N-oxide into its pyridinium salt

Rational Development of Remote C?H Functionalization of Biphenyl: Experimental and Computational Studies

A simple and efficient nitrile-directed meta-C?H olefination, acetoxylation, and iodination of biaryl compounds is reported. Compared to the previous approach of installing a complex U-shaped template to achieve a molecular U-turn and assemble the large-sized cyclophane transition state for the remote C?H activation, a synthetically useful phenyl nitrile functional group could also direct remote meta-C?H activation. This reaction provides a useful method for the modification of biaryl compounds because the nitrile group can be readily converted to amines, acids, amides, or other heterocycles. Notably, the remote meta-selectivity of biphenylnitriles could not be expected from previous results with a macrocyclophane nitrile template. DFT computational studies show that a ligand-containing Pd–Ag heterodimeric transition state (TS) favors the desired remote meta-selectivity. Control experiments demonstrate the directing effect of the nitrile group and exclude the possibility of non-directed meta-C?H activation. Substituted 2-pyridone ligands were found to be key in assisting the cleavage of the meta-C?H bond in the concerted metalation–deprotonation (CMD) process.

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).