42755-95-3

Upstream product

• 51490-01-8 1-(3,4,5-trimethoxyphenyl)-2-bromoethanone 
• 122-52-1 triethyl phosphite 
• 13400-02-7 3,4,5-trimethoxy styrene 
• 762-04-9 phosphonic acid diethyl ester 

Downstream Products

• 42755-99-7 (2-Chloromethyl-cyclopropyl)-(3,4,5-trimethoxy-phenyl)-methanone 

Relevant academic research and scientific papers

Manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds using molecular oxygen in air

A novel aerobic manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds of styrene derivatives and vinyl ethers using diethyl H-phosphonates was developed. This direct transformation of alkenes to β-ketophosphonate readily proceeded at room temperature via the direct incorporation of molecular oxygen present in air (open flask).

Propenone derivatives

The present invention relates to propenone derivatives represented by the following formula (I): STR1 wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR5 (wherein Y represents S or O; and R5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R2 and R3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R2 and R3 are combined to form substituted or unsubstituted methylene or ethylene; R4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.