42771-79-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one is used as an impurity in the production of Flurbiprofen (F598700), which is an anti-inflammatory drug. The application reason for 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one is to serve as a key intermediate in the synthesis of Flurbiprofen, an analgesic medication used to relieve pain and reduce inflammation.
Additionally, due to its structural similarity to Flurbiprofen, 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one may also have potential applications in the development of new anti-inflammatory or analgesic drugs. Further research and development in the pharmaceutical industry could lead to the discovery of novel therapeutic agents based on 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one.

Upstream product

• 77860-49-2 α-(4-cyclohexyl-3-fluorophenyl)ethyl alcohol 
• 87657-78-1 α-Methyl-3-fluoro-4-phenylbenzeneacetamide 
• 5104-49-4 fluorobiprofen 
• 189130-24-3 (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol 
• 56430-76-3 2-(2-fluoro-biphenyl-4-yl)-propionaldehyde 

Downstream Products

• 42771-77-7 1-(2-nitro-1,1'-biphenyl-4-yl)ethan-1-one 

Relevant academic research and scientific papers

Decarboxylative Oxygenation via Photoredox Catalysis

The direct conversion of aliphatic carboxylic acids to their dehomologated carbonyl analogues has been accomplished through photocatalytic decarboxylative oxygenation. This transformation is applicable to an array of carboxylic acid motifs, producing ketones, aldehydes, and amides in excellent yields. Preliminary results demonstrate that this methodology is further amenable to aldehyde substrates via in situ oxidation to the corresponding acid and subsequent decarboxylative oxygenation. We have exploited this strategy for the sequential oxidative dehomologation of linear aliphatic chains.

Photoredox-Catalyzed Decarboxylative Oxidation of Arylacetic Acids

A photoredox-catalyzed decarboxylative oxidation of arylacetic acids, which are privileged scaffolds in pharmaceuticals, is reported herein. The established method is operationally simple and a variety of substrates are applicable, providing rapid access to dehomologated bioisosteres of common pharmaceuticals.

One-step oxidation of 2-arylpropanols to 2-arylpropionic acids: Improving sustainability in the synthesis of profens

Three oxidation procedures were evaluated for the synthesis of optically pure 2-arylpropionic acids. Efficient, mild, and eco-friendly conditions were obtained with the system comprising TEMPO, NaClO, and NaClO2. Thus a series of profens were obtained in good to excellent yields. Georg Thieme Verlag Stuttgart New York.

Chemoenzymatic synthesis of (2S)-2-arylpropanols through a dynamic kinetic resolution of 2-arylpropanals with alcohol dehydrogenases

We applied Horse Liver Alcohol Dehydrogenase (HLADH) to the enantioselective synthesis of six (2S)-2-arylpropanols, useful intermediates in the synthesis of Profens. The influence of substrate structure and reaction conditions on yields and enantioselectivity were investigated. The high yields and high enantioselectivity towards the (S)-enantiomer obtained in the bioreduction of 2-arylpropionic aldehydes, clearly indicate the achievement of a DKR process through a combination of an enzyme-catalyzed kinetic reduction with a chemical base-catalyzed racemization of the unreacted aldehydes. The racemization step is represented by the keto-enol equilibrium of the aldehyde and can be controlled by modulating pH and reaction conditions.

Oxidative conversion of α,α-disubstituted acetamides to corresponding one-carbon-shorter ketones using hypervalent iodine (λ5) reagents in combination with tetraethylammonium bromide

(Chemical Equation Presented) α,α-Disubstituted acetamides undergo oxidative dehomologation to give one-carbon-shorter ketones when reacted with a hypervalent iodine (λ5) reagent in combination with tetraethylammonium bromide (TEAB) in various solvents. In further studies, one such combination of a hypervalent iodine (λ5) reagent, o-iodoxybenzoic acid, and TEAB has been established as a new, mild, efficient, and general method for the transformation.

Process for producing biphenyl derivatives

A process for producing a halobiphenyl derivative represented by the following formula (I) comprises dehydrogenating a cyclohexylhalobenzene represented by the following formula (II) under such conditions that substantially no dehalogenation occurs. STR1 wherein X represents a halogen atom, and each of R1 and R2 independently represents a group represented by the formula STR2 wherein A represents carboxyl or an alkoxycarbonyl group and R represents a hydrogen atom or a lower alkyl group; an alkylcarbonyl; alkenyl; alkynyl; alkyl; aryl; arylcarbonyl; hydroxyalkyl; cyanoalkyl or cyanoalkenyl group.

Therapeutically active phenylalkane derivatives

2-(2-Fluoro-4-biphenylyl)propan-1-ol, 2-(2'-Fluoro-4-biphenylyl)propan-1-ol and 2-(2,2'-Difluoro-4-biphenylyl)propan-1-ol Possessing great anti-inflammatory, analgesic and antipyretic activities.