42771-79-9

Basic information

• Product Name: 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one
• Synonyms: 4-ACETYL-2-FLUOROBPHENYL;3-Fluoro-4-phenyl acetophenone;2-Fluoro-4-acetylbiphenyl;1-(3-Fluoro-4-phenylphenyl)ethan-1-one;FlurBiprofen impurity 4;Flurbiprofen EP Impurity D;1-(2-Fluoro-biphenyl-4-yl)-ethanone
• CAS NO: 42771-79-9
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.24
• EINECS: 255-935-9
• Product Categories: Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 42771-79-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321.8 °C at 760 mmHg
• Flash Point: 132.7 °C
• Appearance: /
• Density: 1.124 g/cm³
• CAS DataBase Reference: 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one(42771-79-9)
• EPA Substance Registry System: 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one(42771-79-9)

Safety Data

• Hazardous Substances Data: 42771-79-9(Hazardous Substances Data)

Usage

Uses

4-Acetyl-2-fluorobiphenyl is an impurity of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Upstream product

• 87657-78-1 α-Methyl-3-fluoro-4-phenylbenzeneacetamide 
• 5104-49-4 fluorobiprofen 
• 189130-24-3 (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol 
• 56430-76-3 2-(2-fluoro-biphenyl-4-yl)-propionaldehyde 
• 77860-49-2 α-(4-cyclohexyl-3-fluorophenyl)ethyl alcohol 

Downstream Products

• 42771-77-7 1-(2-nitro-1,1'-biphenyl-4-yl)ethan-1-one 

Relevant articles and documents

Decarboxylative Oxygenation via Photoredox Catalysis

The direct conversion of aliphatic carboxylic acids to their dehomologated carbonyl analogues has been accomplished through photocatalytic decarboxylative oxygenation. This transformation is applicable to an array of carboxylic acid motifs, producing ketones, aldehydes, and amides in excellent yields. Preliminary results demonstrate that this methodology is further amenable to aldehyde substrates via in situ oxidation to the corresponding acid and subsequent decarboxylative oxygenation. We have exploited this strategy for the sequential oxidative dehomologation of linear aliphatic chains.

One-step oxidation of 2-arylpropanols to 2-arylpropionic acids: Improving sustainability in the synthesis of profens

Three oxidation procedures were evaluated for the synthesis of optically pure 2-arylpropionic acids. Efficient, mild, and eco-friendly conditions were obtained with the system comprising TEMPO, NaClO, and NaClO2. Thus a series of profens were obtained in good to excellent yields. Georg Thieme Verlag Stuttgart New York.

Oxidative conversion of α,α-disubstituted acetamides to corresponding one-carbon-shorter ketones using hypervalent iodine (λ5) reagents in combination with tetraethylammonium bromide

(Chemical Equation Presented) α,α-Disubstituted acetamides undergo oxidative dehomologation to give one-carbon-shorter ketones when reacted with a hypervalent iodine (λ5) reagent in combination with tetraethylammonium bromide (TEAB) in various solvents. In further studies, one such combination of a hypervalent iodine (λ5) reagent, o-iodoxybenzoic acid, and TEAB has been established as a new, mild, efficient, and general method for the transformation.