42779-56-6

Usage

Uses

Used in Organic Synthesis:
2,4-Dichloro-6-picoline is used as a key intermediate for the production of various organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of a wide range of products.
Used in Agrochemicals:
In the agrochemical industry, 2,4-Dichloro-6-picoline is utilized as a vital raw material for the development of pesticides and other agricultural chemicals. Its incorporation into these products helps enhance their effectiveness in protecting crops and improving overall agricultural productivity.
Used in Pharmaceuticals:
2,4-Dichloro-6-picoline plays a significant role in the pharmaceutical industry as a starting material for the synthesis of various drugs. Its chemical properties enable the creation of new drug molecules with potential therapeutic benefits.
Used in Dye Industry:
The dyestuff industry also benefits from the use of 2,4-Dichloro-6-picoline as a raw material. Its chemical structure allows for the development of new dyes with improved color properties and stability, contributing to the production of high-quality textiles and other colored products.

InChI:InChI=1/C6H5Cl2N/c1-4-2-5(7)3-6(8)9-4/h2-3H,1H3

Upstream product

• 3749-51-7 4-hydroxy-6-methyl-2-pyridone 
• 3749-51-7 2,4-dihydroxy-6-methylpyridine 
• 10025-87-3 trichlorophosphate 
• 10026-13-8 phosphorus pentachloride 
• 1314934-13-8 C₆H₉NO₂ 

Downstream Products

• 109-06-8 α-picoline 
• 88912-25-8 4,6-dichloro-2-pyridinecarboxylic acid 
• 3749-51-7 2,4-dihydroxy-6-methylpyridine 
• 1439922-99-2 1-[2-methyl-6-(methylamino)pyridin-4-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carboxamide 
• 1439923-00-8 1-[6-methyl-4-(methylamino)pyridin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carboxamide 
• 851435-28-4 2-chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine 
• 54453-92-8 2-chloro-6-methyl-4-phenylpyridine 
• 132683-62-6 2,4-dichloropyridine-2-carbaldehyde 
• 1404516-65-9 2-chloro-4-(3-methyl-5-methoxyphenoxy)-6-methylpyridine 
• 1404516-66-0 C₁₃H₉ClN₂O 
• 1404516-71-7 2-chloro-4-(3-methoxyphenoxy)-6-methylpyridine 
• 1404516-26-2 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine 
• 1404516-17-1 C₁₉H₁₇NO₂ 
• 1404516-15-9 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol 

Relevant academic research and scientific papers

Small molecule inhibitors of anthrax edema factor

Anthrax is a highly lethal disease caused by the Gram-(+) bacteria Bacillus anthracis. Edema toxin (ET) is a major contributor to the pathogenesis of disease in humans exposed to B. anthracis. ET is a bipartite toxin composed of two proteins secreted by the vegetative bacteria, edema factor (EF) and protective antigen (PA). Our work towards identifying a small molecule inhibitor of anthrax edema factor is the subject of this letter. First we demonstrate that the small molecule probe 5′-Fluorosulfonylbenzoyl 5′-adenosine (FSBA) reacts irreversibly with EF and blocks enzymatic activity. We then show that the adenosine portion of FSBA can be replaced to provide more drug-like molecules which are up to 1000-fold more potent against EF relative to FSBA, display low cross reactivity when tested against a panel of kinases, and are nanomolar inhibitors of EF in a cell-based assay of cAMP production.

Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor

The Plasmodium falciparum orthologue of the human cytokine, macrophage migratory inhibitory factor (PfMIF), is produced by the parasite during malaria infection and modulates the host's immune response. As for other MIF orthologues, PfMIF has tautomerase activity, whose inhibition may influence the cytokine activity. To identify small-molecule inhibitors of the tautomerase activity of PfMIF, virtual screening has been performed by docking 2.1 million compounds into the enzymatic site. Assaying of 17 compounds identified four as active. Substructure search for the most potent of these compounds, a 4-phenoxypyridine analogue, identified four additional compounds that were purchased and also shown to be active. Thirty-one additional analogues were then designed, synthesized, and assayed. Three were found to be potent PfMIF tautomerase inhibitors with Ki of ～40 nM; they are also highly selective with Ki > 100 μM for human MIF.

Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: Mapping of the receptor binding pocket by in silico docking studies

In an effort to discover novel CRF-1 receptor antagonists exhibiting improved physicochemical properties, a dihydropirrole[2,3]pyridine scaffold was designed and explored in terms of the SAR of the substitution at the pendent phenyl ring and the nature of

PYRIDINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR TREATING DISEASES RELATED TO MCH RECEPTOR

The present invention encompasses novel substituted pyridine compounds of Formula (I), which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

Pyridylthio-acylanilide herbicides

Novel herbicidally active pyridylthio-acylanilides of the formula STR1 in which R1, R2 and R3, independently of one another, represent hydrogen, halogen, cyano or trifluoromethyl or alkyl, alkoxy and alkylthio having 1 to 4 carbon atoms in each case, R4 represents halogen, methyl or methoxy, n represents a number 0, 1 or 2, z represents the group (Ia) STR2 or the group (Ib) STR3 where X represents oxygen, sulphur, an N--R10 or N--O--R11 group, or X and Rg tpgether represent the STR4 radical, and the other radicals can have various meanings. Intermediates of the formulae STR5 are also new.