4278-03-9Relevant academic research and scientific papers
Orally efficacious NR2B-selective NMDA receptor antagonists
Claiborne, Christopher F.,McCauley, John A.,Libby, Brian E.,Curtis, Neil R.,Diggle, Helen J.,Kulagowski, Janusz J.,Michelson, Stuart R.,Anderson, Kenneth D.,Claremon, David A.,Freidinger, Roger M.,Bednar, Rodney A.,Mosser, Scott D.,Gaul, Stanley L.,Connolly, Thomas M.,Condra, Cindra L.,Bednar, Bohumil,Stump, Gary L.,Lynch, Joseph J.,Macaulay, Alison,Wafford, Keith A.,Koblan, Kenneth S.,Liverton, Nigel J.
, p. 697 - 700 (2003)
A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a carrageenan-induced rat hyperalgesia model of pain and shows no motor coordination side effects.
Synthesis and Diuretic Profile of 3-(3-Amino-1,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine, an Amiloride-Type Diuretic
Watthey, Jeffrey W. H.,Desai, Mahesh,Rutledge, Richard,Dotson, Ronald
, p. 690 - 692 (2007/10/02)
The synthesis of an analogue of amiloride in which the acylguanidine moiety has been replaced by a 1,2,4-oxadiazol-3-amine unit is described.This substance (3, CGS 4270) exhibited a diuretic profile similar to that of amiloride when evaluated in the rat a
