42785-83-1

Basic information

• Product Name: 1-(1-ethynylcyclohexyl)-3-phenylurea
• Synonyms: 1-(1-ethynylcyclohexyl)-3-phenylurea
• CAS NO: 42785-83-1
• Molecular Weight: 242.321
• Mol File: 42785-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(1-ethynylcyclohexyl)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-ethynylcyclohexyl)-3-phenylurea(42785-83-1)
• EPA Substance Registry System: 1-(1-ethynylcyclohexyl)-3-phenylurea(42785-83-1)

Safety Data

• Hazardous Substances Data: 42785-83-1(Hazardous Substances Data)

Upstream product

• 103-71-9 phenyl isocyanate 
• 30389-18-5 1-Ethynylcyclohexylamine 

Downstream Products

• 42785-75-1 4,4-dimethyl-5-methylene-1-phenylimidazolidin-2-one 
• 1393746-11-6 C₃₃H₄₀F₂N₆O₁₀ 

Relevant articles and documents

Synthesis of Imidazolidin-2-ones and Imidazol-2-ones via Base-Catalyzed Intramolecular Hydroamidation of Propargylic Ureas under Ambient Conditions

The first organo-catalyzed synthesis of imidazolidin-2-ones and imidazol-2-ones via intramolecular hydroamidation of propargylic ureas is reported. The phosphazene base BEMP turned out to be the most active organo-catalyst compared with guanidine and amidine bases. Excellent chemo- and regioselectivities to five-membered cyclic ureas have been achieved under ambient conditions, with a wide substrate scope and exceptionally short reaction times (down to 1 min). A base-mediated isomerization step to an allenamide intermediate is the most feasible reaction pathway to give imidazol-2-ones, as suggested by DFT studies.