427879-64-9Relevant academic research and scientific papers
A photoactivated precipiton for reagent sequestration in solution-phase synthesis
Bosanac, Todd,Wilcox, Craig S.
, p. 4194 - 4195 (2007/10/03)
Precipitons are molecular phase tags for chemical separations. They can be switched from a high-solubility to a low-solubility state to facilitate product, reagent, or catalyst isolation. This paper presents the first photoactivated precipiton and demonstrates that this precipiton is an efficient amine scavenging agent in solution-phase syntheses of amides, ureas, and imines. This approach to amine scavenging offers advantages over solid-phase scavenging methods. The amine is captured in a homogeneous medium, so the capture is much faster than seen with isocyanate resins, and only a small excess of the scavenger is required. Copyright
