427889-63-2

Upstream product

• 378792-35-9 1-(3-O-benzyl-5-O-methylsulfonyl-4-C-methylsulfonyloxymethyl-α-D-ribofuranosyl)thymine 
• 65-71-4 thymin 
• 378792-34-8 methyl (3-O-benzyl-5-O-methylsulfonyl-4-C-methylsulfonyloxymethyl)-D-ribofuranoside 

Downstream Products

• 206055-82-5 (1R,3S,4R,7S)-3-(4-N-benzoyl-5-methylcytosin-1-yl)-1-(4,4'-dimethoxytrityl)oxymethyl-7-(O-2-cyanoethyl-N,N-diisopropylphosphityl)oxy-2,5-dioxabicyclo[2.2.1]heptane 
• 427889-66-5 (1R,3S,4R,7S)-3-(4-N-benzoyl-5-methylcytosin-1-yl)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-2,5-dioxabicyclo[2.2.1]heptane 
• 427889-70-1 1-[1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-(tert-butyl-dimethyl-silanyloxy)-2,5-dioxa-bicyclo[2.2.1]hept-3-yl]-5-methyl-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 
• 427889-65-4 (1R,3S,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-(4,4'-dimethoxytrityl)oxymethyl-3-(5-methylcytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 427889-67-6 (1R,3S,4R,7S)-3-(4-N-benzoyl-5-methylcytosin-1-yl)-1-(4,4'-dimethoxytrityl)oxymethyl-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane 
• 427889-64-3 (1R,3S,4R,7S)-7-(tert-butyldimethylsilyl)oxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

α-LNA (locked nucleic acid with α-D-configuration): Synthesis and selective parallel recognition of RNA

α-LNA is presented as a stereoisomer of LNA (locked nucleic acid) with α-D-configuration. Three different approaches towards the thymine α-LNA monomer as well as the 5-methylcytosine α-LNA monomer are presented. Different α-LNA sequences have been synthesised and their hybridisation with complementary DNA and RNA has been evaluated by means of thermal stability experiments and circular dichroism spectroscopy. In a mixed pyrimidine sequence, α-LNA displays unprecedented parallel-stranded and selective RNA binding. Furthermore, a remarkable selectivity for hybridisation with RNA over DNA is indicated.