427892-72-6

Upstream product

• 73-32-5 L-isoleucine 
• 18598-74-8 (S)-methyl 2-amino-3-methylpentanoate hydrochloride 

Downstream Products

• 934472-29-4 N-(1-sec-butyl-5-hydroxy-pentyl)-4-methyl-benzenesulfonamide 
• 934472-26-1 N-(1-sec-butyl-pent-4-enyl)-4-methyl-benzenesulfonamide 
• 460743-54-8 N-(1-{N'-[2-{4-methylbenzenesulfonylamino}-3-methyl-pentyl]aminomethyl}-2-methylbutyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

An efficient synthetic approach for N-C bond formation from (S)-amino acids: An easy access to cis-2,5-disubstituted chiral piperazines

An efficient synthetic strategy is described for the construction of amino acids derived enantiomerically pure cis-2,5-disubstituted chiral piperazines. Cu-catalyzed spontaneous regioselective ring opening and ring closing of non-activated N-tosyl aziridines as well as Pd-mediated N-C bond formation from N-tosyl halogenated amino-derivatives are the key steps for accessing disubstituted piperazines.

Large scale synthesis of optically pure aziridines

Disclosed is an efficient, inexpensive method for the preparation of chiral aziridines on a large scale.