42833-67-0

Basic information

• Product Name: Methanone, (2-hydroxy-3,4-dimethoxyphenyl)(2,4,6-trimethoxyphenyl)-
• CAS NO: 42833-67-0
• Molecular Formula: C18H20O7
• Molecular Weight: 348.353
• Mol File: 42833-67-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, (2-hydroxy-3,4-dimethoxyphenyl)(2,4,6-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-hydroxy-3,4-dimethoxyphenyl)(2,4,6-trimethoxyphenyl)-(42833-67-0)
• EPA Substance Registry System: Methanone, (2-hydroxy-3,4-dimethoxyphenyl)(2,4,6-trimethoxyphenyl)-(42833-67-0)

Safety Data

• Hazardous Substances Data: 42833-67-0(Hazardous Substances Data)

Upstream product

• 621-23-8 1,2,3-trimethoxybenzene 
• 7169-07-5 3,4,5-(trimethoxy)benzoyl chloride 
• 573-11-5 2,3,4-Trimethoxy-benzoic acid 

Downstream Products

• 3660-86-4 1,3,5,6-tetramethyoxyxanthone 
• 1489235-90-6 1,3,5,6-tetramethoxy-4-phenyl-9H-xanthen-9-one 
• 1489235-91-7 4-(3,5-bis(trifluoromethyl)phenyl)-1,3,5,6-tetramethoxy-9H-xanthen-9-one 
• 1489235-92-8 4-(1,3,5,6-tetramethoxy-9-oxo-9H-xanthen-4-yl)benzaldehyde 
• 1489235-93-9 4-(3,5-difluorophenyl)-1,3,5,6-tetramethoxy-9H-xanthen-9-one 
• 1489235-94-0 1,3,5,6-Tetramethoxy-4-(4-(trifluoromethoxy)phenyl)-9H-xanthen-9-one 
• 1489235-95-1 4-(4-fluorophenyl)-1,3,5,6-tetramethoxy-9H-xanthen-9-one 
• 1489235-96-2 4-(4-ethylphenyl)-1,3,5,6-tetramethoxy-9H-xanthen-9-one 
• 1489235-97-3 1,3,5,6-tetramethoxy-4-p-tolyl-9H-xanthen-9-one 
• 1489235-98-4 4-(4-isopropylphenyl)-1,3,5,6-tetramethoxy-9H-xanthen-9-one 
• 1489235-99-5 1,3,5,6-tetramethoxy-4-(4-(trifluoromethyl)phenyl)-9H-xanthen-9-one 
• 1489236-00-1 4-(4-tert-butylphenyl)-1,3,5,6-tetramethoxy-9H-xanthen-9-one 
• 1489236-01-2 4-(4-acetylphenyl)-1,3,5,6-tetramethoxy-9H-xanthen-9-one 
• 1489236-02-3 methyl 4-(1,3,5,6-tetramethoxy-9-oxo-9H-xanthen-4-yl)benzoate 

Relevant articles and documents

Synthesis and biological evaluation of phenyl substituted polyoxygenated xanthone derivatives as anti-hepatoma agents

A series of novel derivatives of phenyl substituted tetramethoxy xanthone were synthesized and evaluated for their in vitro cytotoxicity against human hepatocellular carcinoma (HCC) and non-tumor hepatic cells. Among these derivatives, compound 6 was more potent than positive control 5-fluorouracil (5-Fu) on QGY-7703 and SMMC-7721 cells with IC50 values of 6.27 μM, 7.50 μM and 15.56 μM, 14.55 μM, respectively. Furthermore, compounds 6, 14, 16, and 29 exhibited much better selectivity toward the normal hepatic cell line QSG-7701 than 5-Fu. Additionally, compound 6 significantly induced cell apoptosis in QGY-7703 cells. Our findings suggested that these phenylxanthone derivatives may hold promise as chemotherapeutic agents for the treatment of human HCC.

γ-Pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones

Norathyriol and its analogues, 1,3,5,6-, 3,4,5,6-, 3,4,6,7- and 2,3,6,7- tetrahydroxyxanthone, were synthesized from benzophenone precursors by Friedel-Crafts acylation and subsequent base-catalyzed cyclization to eliminate methanol. Both 3,4,6,7- and 2,3,6,7-tetrahydroxyxanthone tetraacetate showed potent anti-platelet aggregation effects on arachidonic acid-induced platelet aggregation. 3,4,6,7-Tetrahydroxyxanthone tetraacetate and 1,3,5,6-tetrahydroxyxanthone showed potent and significant anti-platelet aggregation effects on collagen-induced platelet aggregation.