42837-37-6

Basic information

• Product Name: (4-Aminophenyl)piperidin-1-ylmethanone
• Synonyms: ART-CHEM-BB B014353;BUTTPARK 44\02-48;CHEMBRDG-BB 3014353;AKOS B014353;4-(PIPERIDIN-1-YLCARBONYL)PHENYLAMINE;(4-AMINO-PHENYL)-PIPERIDIN-1-YL-METHANONE;TIMTEC-BB SBB000436;(4-Aminophenyl)(1-piperidinyl)methanone
• CAS NO: 42837-37-6
• Molecular Formula: C₁₂H₁₆N₂O
• Molecular Weight: 204.27
• Mol File: 42837-37-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 161-162 °C
• Boiling Point: 402.4 °C at 760 mmHg
• Flash Point: 197.2 °C
• Appearance: /
• Density: 1.155 g/cm³
• Vapor Pressure: 9.34E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 3.56±0.10(Predicted)
• CAS DataBase Reference: (4-Aminophenyl)piperidin-1-ylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Aminophenyl)piperidin-1-ylmethanone(42837-37-6)
• EPA Substance Registry System: (4-Aminophenyl)piperidin-1-ylmethanone(42837-37-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36-36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 42837-37-6(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystalline powder

InChI:InChI=1/C8H9NO2.ClH/c9-5-6-2-1-3-7(4-6)8(10)11;/h1-4H,5,9H2,(H,10,11);1H

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 150-13-0 4-amino-benzoic acid 
• 110-89-4 piperidine 
• 122-04-3 4-nitro-benzoyl chloride 
• 26163-40-6 N-(4-chlorobenzoyl)piperidine 
• 20857-92-5 N-(p-nitrobenzoyl)azacyclohexane 

Downstream Products

• 1456116-50-9 (4-amino-3-(trifluoromethyl)phenyl)(piperidin-1-yl)methanone 
• 72752-65-9 1-{4-[(2-thioxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-piperidine 
• 72752-60-4 1-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-piperidine 
• 104183-46-2 5-Benzylidene-3--4-oxo-thiazolidine-2-thione 
• 76870-22-9 1-(4-Bromo-phenyl)-3-[4-(piperidine-1-carbonyl)-phenyl]-thiourea 
• 76870-23-0 1-Naphthalen-1-yl-3-[4-(piperidine-1-carbonyl)-phenyl]-thiourea 
• 76870-21-8 1-(4-Chloro-phenyl)-3-[4-(piperidine-1-carbonyl)-phenyl]-thiourea 
• 81820-37-3 5-[1-(2-Methoxy-phenyl)-meth-(Z)-ylidene]-2-phenyl-3-[4-(piperidine-1-carbonyl)-phenyl]-3,5-dihydro-imidazol-4-one 
• 81820-33-9 5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-2-phenyl-3-[4-(piperidine-1-carbonyl)-phenyl]-3,5-dihydro-imidazol-4-one 
• 104183-65-5 5-(p-Nitrobenzylidene)-3--4-oxo-thiazolidine-thione 
• 81820-28-2 2-Phenyl-5-[1-phenyl-meth-(Z)-ylidene]-3-[4-(piperidine-1-carbonyl)-phenyl]-3,5-dihydro-imidazol-4-one 
• 104183-54-2 5-(p-Dimethylaminobenzylidene)-3--4-oxo-thiazolidine-2-thione 
• 104183-50-8 5-(p-Methoxybenzylidene)-3--4-oxo-thiazolidine-2-thione 
• 104183-58-6 5-(p-Chlorobenzylidene)-3--4-oxo-thiazolidine-2-thione 

Relevant articles and documents

Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis

Sepsis, a systemic inflammatory response, caused by pathogenic factors including microorganisms, has high mortality and limited therapeutic approaches. Herein, a new soluble epoxide hydrolase (sEH) inhibitor series comprising a phenyl ring connected to a

Indole-2-ketone derivative, preparation method and application thereof

The invention belongs to the field of medicines, particularly relates to an indole-2-ketone derivative, a preparation method and application thereof, and provides a compound represented by the following formula (I), a stereoisomer, a racemate, a tautomer,

Tuneable Copper Catalysed Transfer Hydrogenation of Nitrobenzenes to Aniline or Azo Derivatives

A highly versatile and flexible copper nanoparticle (Cu(0) NPs) catalytic system has been developed for the controlled and selective transfer hydrogenation of nitroarene. Interestingly, the final catalytic product is strongly dependent on the nature of the hydrogen donor source. The yield of nitrobenzene reduction to aniline increased from 20% to an almost quantitative yield over a range of alcohols, diols and aminoalcohols. In glycerol at 130 °C aniline was isolated in 93% yield. In ethanolamine, the reaction was conveniently performed at a lower temperature (55 °C) and gave selectively substituted azobenzene (92% yield). Experimental studies provide support for a reaction pathway in which the Cu(0) NPs catalysed transfer hydrogenation of nitrobenzene to aniline proceeds via the condensation route. The high chemoselectivity of both protocols has been proved in experiments on a panel of variously substituted nitroarenes. Enabling technologies, microwaves and ultrasound, used both separately and in combination, have successfully increased the reaction rate and reaction yield. (Figure presented.).