4284-46-2Relevant academic research and scientific papers
BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF
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Paragraph 00297; 00303-00305, (2021/09/26)
The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled compounds, and prodrugs thereof. The provided compounds may be tumor necrosis factor ("TNF") receptor associated protein 1 ("TRAP1") modulators (e.g., TRAP1 activators). The provided compounds may also rescue the activity in PTEN-induced kinase 1 ("PINK1") loss of function contexts. The provided compounds may also improve mitochondrial health, function, quality, quantity, and/or activity, and/or reduce the production of reactive oxygen species. The provided compounds may also refold or solubilize aggregated or misfolded proteins such as α-synuclein. The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating a disease in a subject in need thereof).
Combined Effect of the Reactant Structure and Medium on Kinetics of Acylation of Arylamines with Arenesulfonyl Chlorides
Kustova,Kuritsyn
, p. 604 - 606 (2007/10/03)
A correlation equation was obtained for the logarithm of the rate constant of acylation of arylamines with arenesulfonyl chlorides in relation to the reactant structure and the nature of the medium. The reliability of this equation for calculation of the rate constants was confirmed by an additional kinetic study of the reactions of arylamines with arenesulfonyl chlorides in propanol, tert-butyl alcohol, and acetonitrile.
