4284-59-7

Basic information

• Product Name: 4-methoxy-2-(toluene-4-sulfonyl)-aniline
• Synonyms: 4-methoxy-2-(toluene-4-sulfonyl)-aniline
• CAS NO: 4284-59-7
• Molecular Weight: 277.344
• Mol File: 4284-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methoxy-2-(toluene-4-sulfonyl)-aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-2-(toluene-4-sulfonyl)-aniline(4284-59-7)
• EPA Substance Registry System: 4-methoxy-2-(toluene-4-sulfonyl)-aniline(4284-59-7)

Safety Data

• Hazardous Substances Data: 4284-59-7(Hazardous Substances Data)

Upstream product

• 1150-26-1 N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide 
• 7664-93-9 sulfuric acid 
• 104-94-9 4-methoxy-aniline 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Photo-Fries rearrangement of N-arylsulfonamides to aminoaryl sulfone derivatives

Photochemical reaction of variously substituted p-toluenesulfonanilides was studied. The reaction gives rearranged products, o- and p-amino-substituted diaryl sulfones with the combined yields of 38-72%: the p-isomer is more favored over the o-isomer with the selectivity ratio of 1.1-4.3 depending on the substituents. N-Alkylation of the sulfonanilides increases the yields of the rearranged products, and e-withdrawing substituents on the N-phenyl ring does not lower the yields drastically. This study provides simple methodology for the synthesis of o- and p-aminoaryl sulfones which are otherwise not easily accessible.