428453-85-4Relevant academic research and scientific papers
A Convenient Synthesis of A-Ring-Functionalized Podolactones. Revision of the Structure of Wentilactone B
Barrero, Alejandro F.,Herrador, Maria M.,Quilez Del Moral, Jose F.,Valdivia, Monica V.
, p. 1379 - 1382 (2002)
(Matrix Presented) A new route to podolactones functionalized in the A ring has been achieved. Two key steps were employed in this synthesis, the construction of the bicyclic skeleton via a Mn(III)-mediated radical cyclization and the transformation of this bicyclic intermediate into the tetracyclic podolactone skeleton through a Pd (II)-mediated bislactonization of the corresponding conjugate diene. The reported synthesis of 3β-hydroxy-13,14,15,-16-tetranorlabda-7,9(11)-dien-(19,6β),(12,17)- diolide (1) let us reassign the structure of wentilactone B, for which structure 1 was wrongly reported.
