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5',2'-bis-O-trityl-5-methyluridine is a chemical compound derived from uridine, a nucleoside that plays a crucial role in RNA synthesis. In this specific compound, the 5' and 2' hydroxyl groups of the ribose sugar are protected by trityl groups, which are bulky phenylmethyl groups. Additionally, the 5-methyl group is attached to the uracil base, providing further structural modification. 5',2'-bis-O-trityl-5-methyluridine is often used in organic synthesis and biochemistry, particularly in the preparation of modified nucleosides and oligonucleotides for research purposes. The trityl groups help prevent unwanted side reactions during synthesis, and they can be removed later when needed, making 5',2'-bis-O-trityl-5-methyluridine a valuable intermediate in the development of novel nucleic acid analogs with potential applications in medicine and biotechnology.

4285-00-1

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4285-00-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4285-00-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,8 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4285-00:
(6*4)+(5*2)+(4*8)+(3*5)+(2*0)+(1*0)=81
81 % 10 = 1
So 4285-00-1 is a valid CAS Registry Number.

4285-00-1Downstream Products

4285-00-1Relevant academic research and scientific papers

Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues

McGuigan, Christopher,Serpi, Michaela,Slusarczyk, Magdalena,Ferrari, Valentina,Pertusati, Fabrizio,Meneghesso, Silvia,Derudas, Marco,Farleigh, Laura,Zanetta, Paola,Bugert, Joachim

, p. 227 - 235 (2016)

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.

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