4285-67-0

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-(3,4-dichlorophenyl)-2-methyl-
• Synonyms: 3-(3,4-dichlorophenyl)-2-methylquinazolin-4-one;3-(3,4-dichlorophenyl)-2-methylquinazolin-4(3H)-one;3-(3,4-Dichloro-phenyl)-2-methyl-3H-quinazolin-4-one;2-Methyl-3-(3,4-dichlorophenyl)-3H-quinazolin-4-one;3-<3.4-Dichlor-phenyl>-2-methyl-chinazolon-(4)
• CAS NO: 4285-67-0
• Molecular Formula: C15H10Cl2N2O
• Molecular Weight: 305.163
• Mol File: 4285-67-0.mol

Chemical Properties

• Melting Point: 164 - 165 °C
• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-(3,4-dichlorophenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-(3,4-dichlorophenyl)-2-methyl-(4285-67-0)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-(3,4-dichlorophenyl)-2-methyl-(4285-67-0)

Safety Data

• Hazardous Substances Data: 4285-67-0(Hazardous Substances Data)

Upstream product

• 78-39-7 Triethyl orthoacetate 
• 65960-74-9 2-amino-N-(3,4-dichlorophenyl)benzamide 
• 123-54-6 acetylacetone 

Relevant articles and documents

A quinazoline compound and its synthesis method

The invention discloses a synthetic method of a quinazolinone compound. The method can be used for preparing the quinazolinone compound by carrying out reaction at a proper temperature and time by taking a 2-aminobenzamide derivative and a 1, 3-diketone compound as raw materials, taking chiral Bronsted acid or Lewis acid as a catalyst and water and biodegradable ethyl lactate and polyethylene glycol as a mixed solvent. The synthetic method of the quinazolinone compound provided by the invention is mild in reaction condition, low in cost, environment-friendly, high in yield and suitable for industrial production.

FeCl3-catalyzed tandem condensation/intramolecular nucleophilic addition/C-C bond cleavage: A concise synthesis of 2-substitued quinazolinones from 2-aminobenzamides and 1,3-diketones in aqueous media

A concise approach for the synthesis of 2-substituted quinazolinones using an iron-catalyzed tandem reaction of 2-aminobenzamides with acyclic or cyclic 1,3-diketones via condensation, intramolecular nucleophilic addition, C-C bond cleavage in an aqueous solution of poly(ethylene glycol) under oxidant-free conditions has been developed.

Compounds for modulating TRPV3 function

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Br?nsted acid-catalyzed selective C-C bond cleavage of 1,3-diketones: A facile synthesis of 4(3H)-quinazolinones in aqueous ethyl lactate

A facile and green approach was developed for the synthesis of 4(3H)-quinazolinones by using camphorsulfonic acid as a catalyst in an aqueous solution of biodegradable ethyl lactate. Various 2-aryl-, 2-alkyl-, and 2-(4-oxoalkyl)quinazolinones were obtained by cyclization of 2-aminobenzamides with a wide range of acyclic or cyclic 1,3-diketones via C-C bond cleavage in satisfactory to excellent yields.

Compounds for modulating TRPV3 function

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.