428509-75-5Relevant academic research and scientific papers
New developments in the synthesis of heterotopic atropisomeric diphosphines via diastereoselective aryl coupling reactions
Madec, Jonathan,Michaud, Guillaume,Genet, Jean-Pierre,Marinetti, Angela
, p. 2253 - 2261 (2004)
The new heterotopic atropisomeric diphosphine (R)-5,6-benzo-2,2′- bis(diphenylphosphino)-4′,5′,6′-trimethylbiphenyl has been prepared. The key step of this synthesis is a diastereoselective, intramolecular aryl-aryl coupling reaction via oxidation of a suitable, chiral diarylcuprate. The catalytic properties of the diphosphine in ruthenium promoted hydrogenations of model substrates and in rhodium promoted 1,4-additions of boronic acids to α,β-unsaturated ketones are fully comparable to those of reference ligands such as BINAP. This seems to indicate that C2-symmetry is not a structural prerequisite for atropisomeric chiral diphosphines to obtain high enantioselectivities in 1,4-addition reactions as well as in hydrogenation reactions.
The metal complex and homochiral diphosphines
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Page 25-26, (2010/02/11)
Novel chiral diphosphines (R) or (S), and their use as optically active ligand for preparing diphosphino-metallic complexes, and the diphosphino-metallic complexes containing said chiral diphosphines (R) or (S), and the use of the diphosphino-metallic com
