428518-36-9 Usage
Uses
Used in Pharmaceutical Industry:
(R)-1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester is used as an intermediate in the synthesis of pharmaceutical compounds for its ability to be modified and incorporated into various drug molecules. Its presence of functional groups allows for further chemical reactions, making it a versatile building block in the development of new medications.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester serves as a key component in the creation of complex organic molecules. Its functional groups enable it to participate in a range of reactions, facilitating the synthesis of target compounds for various applications.
Used in Production of Other Organic Compounds:
(R)-1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester is utilized as a precursor in the production of other organic compounds, leveraging its structural features to generate a diverse array of chemical products. Its versatility in undergoing various chemical transformations makes it a valuable asset in the synthesis of specialty chemicals and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 428518-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,8,5,1 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 428518-36:
(8*4)+(7*2)+(6*8)+(5*5)+(4*1)+(3*8)+(2*3)+(1*6)=159
159 % 10 = 9
So 428518-36-9 is a valid CAS Registry Number.
428518-36-9Relevant academic research and scientific papers
A chemoenzymatic approach to the synthesis of enantiomerically pure aza analogues of paraconic acid methyl ester and both enantiomers of methyl β-proline
Felluga, Fulvia,Pitacco, Giuliana,Prodan, Massimo,Pricl, Sabrina,Visintin, Marco,Valentin, Ennio
, p. 3241 - 3249 (2007/10/03)
Enantiopure methyl esters of 1-alkyl-5-oxo-3-pyrrolidinecarboxylic acids were obtained by enzymatic resolution of the corresponding chiral racemic mixtures. A particularly favourable interaction, also supported by molecular mechanics calculations, was observed between the 1-benzyl derivative and α-chymotrypsin, for which the enantiomeric ratio, E, exceeded 200. The absolute configurations of the lactams were determined by means of CD spectroscopy. From the resulting enantiomerically pure (99% e.e.) (S)-(+)-1-benzyl-3-pyrrolidinecarboxylic acid and methyl (R)-(-)-1-benzyl-3-pyrrolidinecarboxylate, the methyl esters of (+) and (-)-β-proline were synthesised in 99% e.e. and 18 and 22% overall yield, respectively.
