42856-47-3Relevant academic research and scientific papers
Cleavage of 1,3-dicarbonyls through oxidative amidation
Biallas, Phillip,H?ring, Andreas P.,Kirsch, Stefan F.
supporting information, p. 3184 - 3187 (2017/04/21)
A mild and convenient protocol for the oxidative cleavage of 1,3-diketone compounds is described. Under metal-free conditions, the method converts the 1,3-dicarbonyls into amides when treated with (nBu4N)N3 and iodine in the presence of an amine at room temperature. Using this method, a range of 1,3-dicarbonyls with various structural motifs including sterically demanding substituents and ordinary functional groups were easily fragmented, and it is demonstrated that cyclic 1,3-dicarbonyls can be directly transformed into acyclic diamides through ring-opening. Initial mechanistic studies show that diazidation of the enol form is followed by nucleophilic substitution with the amine.
Hydrogen bond organocatalysis of benzotriazole in transamidation of carboxamides with amines
Nguyen, Thanh Binh,Ermolenko, Ludmila,Dau, Marie-Elise Tran Huu,Al-Mourabit, Ali
, p. 403 - 416 (2014/01/17)
A new method of transamidation of carboxamides with amines catalyzed by benzotriazole has been developed.
