42864-89-1Relevant academic research and scientific papers
1-(3,4-DIMETHOXYPHENETHYLAMINO)-3-(PHENOXY)-2-PROPANOLS
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, (2014/02/08)
1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2-propanols; and acid-addition salts. The substituent in the 3-(substituted phenoxy) group can be lower alkoxy, chloro, cyano, hydroxymethyl, acetyl, or o-allyl. The compounds are pharmacological agents, especially beta-adrenergic blocking agents with cardio-selective activity. They can be produced by reacting a 1-halo-3-(substituted phenoxy)-2-propanol with 3,4-dimethoxyphenethylamine; or by reacting a 1, 2-epoxy-3-(substituted phenoxy)propane with 3,4-dimethoxyphenethylamine. Starting materials for use in those processes are obtained by reacting a phenol or a sodium phenolate with epichlorohydrin under varying conditions.
