42882-83-7Relevant academic research and scientific papers
Metal-Free Synthesis of Pyrazoles from 1,3-Diarylpropenes and Hydrazines via Multiple Inter-/Intramolecular C–H Aminations
Tang, Li,Ma, Minyan,Zhang, Qi,Luo, Huan,Wang, Tao,Chai, Yonghai
supporting information, p. 2610 - 2620 (2017/08/16)
A facile and metal-free access to pyrazoles from 1,3-diarylpropenes and hydrazines via multiple inter-/intramolecular C-H aminations was described. Under the neutral and mild 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) oxidative conditions, various disubstituted pyrazoles were synthesized in moderate to excellent yields. This method provides a pot- and step-economic strategy for the construction of pyrazoles, especially those for drug discovery. (Figure presented.).
Method for preparing pyrazole compound
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Paragraph 0024; 0025; 0026; 0027; 0088; 0089; 0090; 0091, (2017/08/28)
The invention discloses a method for preparing a pyrazole compound. A substituted propylene compound and p-toluenesulfonhydrazide serve as raw materials, 2,3-dichloro-5,6-dicyan-1,4-benzoquinone serves as an oxidant, and the pyrazole compound is synthesized through a dehydrogenation coupling reaction. The method is easy to operate, reaction conditions are mild, no catalysts need to be added, and the pyrazole compound can be synthesized by means of a simple substrate not needing functionalization at a medium or high yield.
Base-promoted ecofriendly synthesis of trisubstituted pyrazoles from α,β-alkynyl N-tosylhydrazones under metal- and solvent-free conditions
Li, Ning,Li, Baoguo,Chen, Shufeng
, p. 1597 - 1601 (2016/06/14)
A simple and green method is described for the synthesis of trisubstituted pyrazoles from α,β-alkynyl N-tosylhydrazones under metal- and solvent-free conditions. Notably, only diisopropylamine is required as a promoter, and the reaction can be easily perf
