428839-21-8

Basic information

• Product Name: C₂₃H₁₇FN₂O₃S
• CAS NO: 428839-21-8
• Molecular Weight: 420.464
• Mol File: 428839-21-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₇FN₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₇FN₂O₃S(428839-21-8)
• EPA Substance Registry System: C₂₃H₁₇FN₂O₃S(428839-21-8)

Safety Data

• Hazardous Substances Data: 428839-21-8(Hazardous Substances Data)

Upstream product

• 656-32-6 N-(2-fluorophenyl)thiourea 
• 97220-61-6 3-bromo-3-(4-phenoxybenzoyl)propionic acid 

Relevant articles and documents

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

Structure-activity relationships of three related series of 4-phenylthiazol-5-ylacetic acids, derived from two hits emanating from a focused library obtained by in silico screening, have been explored as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) antagonists. Several compounds with double digit nanomolar binding affinity and full antagonistic efficacy for human CRTH2 receptor were obtained in all subclasses. The most potent compound was [2-(4-chloro-benzyl)-4-(4-phenoxy-phenyl)-thiazol-5-yl]acetic acid having an binding affinity of 3.7 nM and functional antagonistic effect of 66 nM in a BRET and 12 nM in a cAMP assay with no functional activity for the other PGD2 DP receptor (27 μM in cAMP).