428854-16-4Relevant academic research and scientific papers
Cationic hypericin derivatives as novel agents with photobactericidal activity: Synthesis and photodynamic inactivation of propionibacterium acnes
Hager, Beate,Strauss, Wolfgang S. L.,Falk, Heinz
experimental part, p. 1201 - 1206 (2010/07/17)
The present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. Uncharged hypericin derivatives with attached C2-linkers leading to a pyridyl or a 4-dimethylaminophenyl residue
Concerning the absorption and photochemical properties of an ω-4-dimethylaminobenzal hypericin derivative
Obermueller,Falk
, p. 1519 - 1526 (2007/10/03)
A hypericin derivative containing ω,ω′ -4-dimethylaminobenzal residues was shown to undergo an intramolecular [2 + 2] cycloaddition upon irradiation leading to a cyclobutane derivative whose main absorption band is hardly shifted as compared to hypericin. The corresponding ω-substituted derivative displayed a 34 nm bathochromic shift and a strongly reduced fluorescence quantum yield rendering it a nice candidate for a photodynamic therapy agent. Unfortunately, however, it produced virtually no photosensitized active oxygen species, making it thus unsuited for this purpose.
