428861-44-3

Basic information

• Product Name: 1H-Indole-2-carboxylicacid,2,3-dihydro-5-nitro-(9CI)
• Synonyms: 1H-Indole-2-carboxylicacid,2,3-dihydro-5-nitro-(9CI)
• CAS NO: 428861-44-3
• Molecular Formula: C9H8N2O4
• Molecular Weight: 208.17082
• Product Categories: AMINOACID
• Mol File: 428861-44-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 470.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.501±0.06 g/cm3(Predicted)
• PKA: 3.41±0.20(Predicted)
• CAS DataBase Reference: 1H-Indole-2-carboxylicacid,2,3-dihydro-5-nitro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxylicacid,2,3-dihydro-5-nitro-(9CI)(428861-44-3)
• EPA Substance Registry System: 1H-Indole-2-carboxylicacid,2,3-dihydro-5-nitro-(9CI)(428861-44-3)

Safety Data

• Hazardous Substances Data: 428861-44-3(Hazardous Substances Data)

Upstream product

• 16851-56-2 indolin-2-yl carboxylic acid 

Downstream Products

• 157649-56-4 5-nitro-1H-indole-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of methyl 5- and 6-nitroindole-2-carboxylates by nitration of indoline-2-carboxylic acid

Indoline-2-carboxylic acid was transformed into 6-nitroindoline-2-carboxylic acid, the methyl ester of which was easily dehydrogenated by DDQ to methyl 6-nitroindole-2-carboxylate (total yield: 67%). Methyl 5-nitroindole-2-carboxylate was obtained by the nitration of methyl 1-acetylindoline-2-carboxylate acid followed by dehydrogenation with MnO2 in toluene in 40% total yield.