428868-18-2Relevant academic research and scientific papers
Synthesis of cyclic constrained β-oxo-substituted α-amino acids
Krikstolaityte, Sonata,Hammer, Kristin,Romming, Christian,Undheim, Kjell
, p. 571 - 580 (2002)
Ru(II)-catalyzed RCM reaction with a 5,5-diene of (2R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine provided a spiroannulated cyclohexenone as substrate for conjugate additions of organocuprates. Acid hydrolysis gave β-oxo-substituted α-amino acids. Assignments of configurations are based on single crystal X-ray analyses.
