428868-35-3 Usage
Biochem/physiol Actions
WAY-163909 is a 5-hydroxytryptamine receptor 2C (5-HT2C) agonist (EC50/Emax = 8 nM/90% vs. 185 nM/40%/5-HT2B; Ki = 10.5 nM/5-HT2C, 212 nM/5-HT2A, 343 nM/5-HT7, 485 nM/5-HT2B, 245 nM/D4, 665 nM/rat α-1, >1 μM/5-HT1A, D2, D3, rat 5-HT-T) with no 5-HT2A-stimulatory potency. WAY-163909 exhibits anorectic (ED50 in mg/kg via i.p. = 1.4/DIO mice and 5.19/Zucker rats), antipsychotic (morphine-induced mouse climbing ID50 = 10.69 mg/kg i.p.; rat avoidance responding reduction ED50 = 1.27 mg/kg i.p. and 6.50 mg/kg p.o.) and antidepressant (10 mg/kg, i.p. or s.c. in forced rat swimming test ; 3 mg/kg/day i.p. in reducing olfactory bulbectomy/BULB-induced hyperactivity in rats) efficacy in vivo.
Check Digit Verification of cas no
The CAS Registry Mumber 428868-35-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,8,8,6 and 8 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 428868-35:
(8*4)+(7*2)+(6*8)+(5*8)+(4*6)+(3*8)+(2*3)+(1*5)=193
193 % 10 = 3
So 428868-35-3 is a valid CAS Registry Number.
428868-35-3Relevant articles and documents
Imaging evaluation of 5HT2C agonists, [11C]WAY-163909 and [11C]vabicaserin, formed by Pictet-Spengler cyclization
Neelamegam, Ramesh,Hellenbrand, Tim,Schroeder, Frederick A.,Wang, Changning,Hooker, Jacob M.
, p. 1488 - 1494 (2014)
The serotonin subtype 2C (5HT2C) receptor is an emerging and promising drug target to treat several disorders of the human central nervous system. In this current report, two potent and selective 5HT2C full agonists, WAY-163909 (2) a
