42887-47-8 Usage
Derivative of tetrahydroisoquinoline
A heterocyclic compound commonly found in natural products This indicates that the compound is derived from a parent structure, tetrahydroisoquinoline, which is a type of heterocyclic compound that contains a ring structure with one or more heteroatoms (atoms other than carbon), and is commonly found in natural products.
Potential therapeutic properties
Particularly in the treatment of neurodegenerative diseases and substance abuse disorders The compound has shown promise in treating certain medical conditions, specifically those related to the nervous system, such as neurodegenerative diseases (e.g., Parkinson's disease) and substance abuse disorders.
Modulation of dopamine and serotonin systems in the brain
A potential drug target for conditions such as Parkinson's disease and addiction The compound has been studied for its ability to interact with and regulate the dopamine and serotonin systems in the brain, which are neurotransmitter systems involved in various cognitive and emotional processes. This makes it a potential target for drug development in treating conditions related to these systems, such as Parkinson's disease and addiction.
Unique structure and biological activity
A valuable subject for further research and drug development The compound's distinct chemical structure and its effects on biological processes make it an important subject for continued research and the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 42887-47-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,8,8 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 42887-47:
(7*4)+(6*2)+(5*8)+(4*8)+(3*7)+(2*4)+(1*7)=148
148 % 10 = 8
So 42887-47-8 is a valid CAS Registry Number.
42887-47-8Relevant articles and documents
Fluorometric determination of 1,2,3,4-Tetrahydro-6,7- dihydroxyisoquinoline in biological materials by HPLC
Shirahata, Akira,Yoshioka, Masanori,Tamura, Zenzo
, p. 1814 - 1819 (2007/10/03)
In the belief that endogenous 1,2,3,4-tetrahydro-6,7- dihydroxyisoquinoline (DA-Fp) could be a potential marker involved in the etiology of various diseases such as Parkinsonism, we attempted to develop a fluorescence method for DA-Fp. It was synthesized by condensation of dopamine with formaldehyde according to an established method. Periodate was identified by screening from various oxidation reagents as a fluorescence reagent to DA-Fp. Optimal reaction conditions were obtained with 0.25 mM NaIO4 in 0.1 M phosphate buffer (pH 8.0) at 37 °C for 15 min. The fluorescence spectrum of the derivative showed that we had found new reaction specific for DA-Fp. This reaction was coupled on-line to high performance liquid chromatography (HPLC, which enabled us to achieve a highly sensitive method for determining DA-Fp. A working curve was linear from 2 to 800 pmol of DA-Fp per injection. To determine DA-Fp in biological materials, the pretreatment before HPLC was optimized by hydrolysis of its conjugate and suppression of the artifact with l-phenylephrine. Urinary excretion of DA-Fp in men was measured by this new present method. The urinary excretion of endogenous DA-Fp increased in a rabbit given L-DOPA. The DA-Fp concentration was determined in rat brain. The significance of DA-Fp in these biological materials is discussed and evaluated. We conclude that the present method will be useful for studying tetrahydroisoquinolines involved in many diseases.
