428871-29-8Relevant academic research and scientific papers
Identification of novel benzimidazole series of potent and selective ORL1 antagonists
Okamoto, Osamu,Kobayashi, Kensuke,Kawamoto, Hiroshi,Ito, Satoru,Satoh, Atsushi,Kato, Tetsuya,Yamamoto, Izumi,Mizutani, Sayaka,Hashimoto, Masaya,Shimizu, Atsushi,Sakoh, Hiroki,Nagatomi, Yasushi,Iwasawa, Yoshikazu,Takahashi, Hiroyuki,Ishii, Yasuyuki,Ozaki, Satoshi,Ohta, Hisashi
scheme or table, p. 3278 - 3281 (2009/04/05)
Structure-activity studies on benzimidazole lead 1 obtained from library screening led to the discovery of potent and selective ORL1 antagonist 28, 5-chloro-2-[(1-ethyl-1-methylpropyl)thio]-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1H-benzimidazole, which is s
BENZIMIDAZOLE DERIVATIVES
-
, (2008/06/13)
This invention relates to the compounds represented by a general formula [I]: ???[in which A1 and A2 represent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C3-C20 aliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.
