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ACTH (6-9), also known as adrenocorticotropic hormone (6-9), is a synthetic peptide consisting of four amino acids derived from the larger ACTH molecule. ACTH is a hormone produced by the pituitary gland that stimulates the adrenal cortex to produce cortisol and other steroid hormones. The (6-9) fragment refers to the specific sequence of amino acids within the ACTH molecule, which is believed to have potential therapeutic applications. Research has shown that ACTH (6-9) may have neuroprotective and anti-inflammatory properties, making it a subject of interest in the development of treatments for neurodegenerative diseases and other conditions. However, further studies are needed to fully understand its mechanisms of action and potential clinical applications.

4289-02-5

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4289-02-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4289-02-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,8 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4289-02:
(6*4)+(5*2)+(4*8)+(3*9)+(2*0)+(1*2)=95
95 % 10 = 5
So 4289-02-5 is a valid CAS Registry Number.
InChI:InChI=1/C32H40N10O5/c33-23(14-21-16-37-17-40-21)28(43)19-9-7-18(8-10-19)12-24(34)29(44)41-26(6-3-11-38-32(35)36)30(45)42-27(31(46)47)13-20-15-39-25-5-2-1-4-22(20)25/h1-2,4-5,7-10,15-17,23-24,26-27,39H,3,6,11-14,33-34H2,(H,37,40)(H,41,44)(H,42,45)(H,46,47)(H4,35,36,38)/t23-,24-,26-,27-/m0/s1

4289-02-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-[[(2S)-2-[[(2S)-2-amino-3-[4-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]phenyl]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid

1.2 Other means of identification

Product number -
Other names L-Tryptophan,N-(N2-(N-L-histidyl-L-phenylalanyl)-L-arginyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4289-02-5 SDS

4289-02-5Upstream product

4289-02-5Downstream Products

4289-02-5Relevant academic research and scientific papers

Stability of His-Phe-Arg-Trp-Pro-Gly-Pro to Leucine Aminopeptidase, Carboxypeptidase Y, and Rat Nasal Mucus, Blood, and Plasma

Shevchenko,Dulov,Andreeva,Nagaev,Shevchenko,Radilov,Myasoedov

, p. 153 - 161 (2016/04/19)

The His-Phe-Arg-Trp-Pro-Gly-Pro [ACTH-(6-9)-PGP] peptide was synthesized. Proteolysis of ACTH-(6-9)-PGP and semax (Met-Glu-His-Phe-Pro-Gly-Pro) in the presence of leucine aminopeptidase and carboxypeptidase Y was studied. If the proteolysis of ACTH-(6-9)-PGP is mainly defined by aminopeptidases, the basic metabolite is Trp-Pro-Gly-Pro. Identification of major metabolites of ACTH-(6-9)PGP when incubated with the enzymes in vitro made it possible to evaluate proteolysis pathways of the peptide and prepare necessary amounts of its metabolites for using them as standards. Kinetics of ACTH-(6-9)PGP degradation in the presence of enzyme systems of nasal mucus, blood, and plasma were also explored. It was found that proteolysis of ACTH-(6-9)-PGP in rat blood and plasma occurs mainly under the effect of enzymes whose action is similar to leucine aminopeptidase.

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