42890-06-2

Upstream product

• 82267-01-4 (2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile 
• 52492-43-0 2,5-anhydro-3,4,6-tri-O-benzyl-D-allononitrile 
• 532-20-7 D-Ribose 
• 1824-96-0 methyl ribofuranoside 
• 64363-77-5 methyl 2,3,5-tri-O-benzyl-D-ribofuranoside 
• 16838-89-4 2,3,5-tri-O-benzyl-D-ribofuranose 
• 58381-23-0 (3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-yl acetate 

Downstream Products

• 136409-47-7 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 136409-52-4 4-methyl-2-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)quinoline 
• 136409-53-5 4-methyl-2-(2',3',5'-tri-O-benzyl-β-D-ribofuranosyl)quinoline 
• 136409-54-6 methyl 2-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)isonicotinate 
• 136409-55-7 methyl 2-(2',3',5'-tri-O-benzyl-β-D-ribofuranosyl)isonicotinate 
• 113889-66-0 1-(2',3',5'-tri-O-benzyl-β-D-ribofuranosyl)-2-phenylacetylene 
• 851787-48-9 (2S,3S,4R,5R)-2-([1,1'-biphenyl]-4-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran 

Relevant academic research and scientific papers

ANTIVIRAL NUCLEOSIDES AND DERIVATIVES THEREOF

Disclosed herein are nucleoside compounds and derivatives thereof, pharmaceutical compositions containing same, and their methods of synthesis. The compounds are useful in treating orthomyxovirus infections, such as influenza infections.

Synthesis of C-Nucleosides via Radical Coupling Reaction

Photolysis of O-acyl derivatives of N-hydroxy-2-thiopyridone, prepared from tetrahydrofuran-2-carboxylic acid, D-ribofuranosylmethanoic acid, and D-ribopyranosylmethanoic acid, gave the corresponding C-nucleoside derivatives in the presence of heteroaromatic compounds via radical pathways.The essential step in this method is a radical coupling reaction of D-ribofuranosyl radical or D-ribopyranosyl radical and some heteroaromatic bases.This is a new method for the preparation of C-nucleosides using sugar carboxylic acids.

4-AMINO-3-(2,3,5-TRI-O-BENZYL-β-D-RIBOFURANOSYL)-5-PYRAZOLECARBONITRILE. SYNTHESIS AND CONVERSION INTO A SUGAR-BLOCKED 5,7-DISUBSTITUTED FORMYCIN ANALOG

The title compound, a potential intermediate to protected C-nucleoside analogs related to formycin A, was synthesized via a new route wherein 2,3,5-tri-O-benzyl-1-O-(p-nitrophenyl)-D-ribofuranose was converted to 2,5-anhydro-3,4,6-tri-O-benzyl-D-allonic a