42908-43-0Relevant academic research and scientific papers
Spiro- and bridged-ring forming electrophile induced -> grime -> nitrone cycloaddition cascades. Multiplication of chirality
Dondas, H. Ali,Grigg, Ronald,Frampton, Christopher S.
, p. 5719 - 5722 (1997)
Electrophile induced 6-exo-trig spirocyclisation of oximes onto 5-, 6- or 7-membered cycloalkenes occurs stereo- and regio- specifically in good yield. Bridged - ring forming cyclisations creating bicycle-[3.3.1]- and bicyclo-[3.2.1]-ring systems also occur in good yield. Chiral bridged-ring systems have been synthesised, via the latter processes, that involve multiplication of chiral centres from one to six and seven in one pot reactions.
