42924-82-3

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 140837-82-7 ethyl (2E)-3-(3-indolyl)-2-methylprop-2-enoate 

Downstream Products

• 1508307-31-0 (E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide 
• 1508307-27-4 (E)-N-(4-(tert-butyl)phenyl)-3-(1H -indol-3-yl)-2-methylacrylamide 

Relevant academic research and scientific papers

Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents

Novel compounds containing polar and nonpolar substitutions on the prop-2-en-1-on linker of the trans-indol-3-ylacrylamide scaffold were designed by modeling within the colchicine site of tubulin and then synthesized to determine the role of such substitu

Indole compound with selective inhibitory activity of genome replication of HCV, method for preparing the same, and pharmaceutical composition comprising the same for preventing or treating hepatitis C

The present invention relates to an indole based compound having a selective inhibiting activity on genome replication of the hepatitis C virus, a production method for same, and a pharmaceutical composition for preventing or treating hepatitis C containi

Synthesis and structure-activity relationship of novel indole acrylamide derivatives as hcv replication inhibitors

Aseries of indole acrylamide derivatives were synthesized and evaluated for their inhibitory effects on hepatitis C virus (HCV) replication. Previously, we have identified (E)-N-(4- tert-butylphenyl)-3-(5-cyano-1H-indol-3-yl)-2-methylacrylamide (6c) as on

Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors

In order to identify the inhibitors of hepatitis C virus (HCV) replication with a novel scaffold via a mechanistically unbiased approach, we screened our in-house library composed of ～6000 compounds with various chemical structures by using the renilla lu