42951-68-8

Usage

Class

Heterocyclic organic compound

Type

Pyrazole derivative

Common uses

Pharmaceutical and drug development research, potential kinase inhibitor, potential antitumor agent

Synthesis utility

Versatile reactivity for the synthesis of other organic compounds and materials

Upstream product

• 4604-05-1 2-chloro-4,6-diphenyl-pyridine-3-carbonitrile 
• 58327-74-5 4,6-diphenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 129167-85-7 3-Cyano-4,6-diphenyl-pyridine-2-sulfonyl chloride 

Downstream Products

• 151052-52-7 Cyano-[(4,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-hydrazono]-acetic acid ethyl ester 
• 151052-53-8 2-[(4,6-Diphenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-hydrazono]-malononitrile 
• 151052-54-9 2-[(4,6-Diphenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-hydrazono]-malonic acid diethyl ester 
• 136271-33-5 2,4,6-Triphenyl-7-o-tolylazo-1,5,8a,9-tetraaza-fluoren-8-ol 
• 136271-36-8 7-(4-Bromo-phenylazo)-2,4,6-triphenyl-1,5,8a,9-tetraaza-fluoren-8-ol 
• 136271-35-7 7-(2-Methoxy-phenylazo)-2,4,6-triphenyl-1,5,8a,9-tetraaza-fluoren-8-ol 
• 136271-34-6 7-(4-Nitro-phenylazo)-2,4,6-triphenyl-1,5,8a,9-tetraaza-fluoren-8-ol 
• 151052-56-1 3-[(4,6-Diphenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-hydrazono]-pentane-2,4-dione 
• 151052-55-0 2-[(4,6-Diphenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-hydrazono]-3-oxo-butyric acid ethyl ester 

Relevant academic research and scientific papers

EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER

The present invention is directed to compounds of generic formula (I) which are inhibitors of ephrin A4. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatm

Heterocyclic Synthesis with 3-Cyano-2(1H)pyridinethione: Synthesis of 3-Oxo-2,3-dihydroisothiazolopyridine and Related Compounds

3-Carbethoxy-4,6-diphenyl-2-pyridine sulfonamide (5), can be cyclized to 3-oxo-2,3-dihydro-4,6-diphenylisothiazolopyridine-1,1-dioxide (2).Oxidation of pyridinethione 6 with Cl2/ H2O gave the sulfonyl chloride derivative 7, which can be ammonolyzed to 3-amino-4,6-diphenylisothiazolopyridine-1,1-dioxide (8), and 3-cyano-4,6-diphenylpyridine-2-sulfonamide (9).Hydrolysis of 6 gave 3-carboxamido-2(1H)pyridinethione (12) which can be oxidized with iodine to 3-oxo-4,6-diphenyl-2,3-dihydroisothiazolopyridine (13). 3-Methyl-4,6-diphenylisothiazolopyridine-1,1-dioxide (17) was also prepared from 6.