429676-75-5

Upstream product

• 352695-17-1 (1RS,2S)-2-(3-hydroxy-propyl)-2-methyl-cyclohexanol 
• 53068-89-6 (S)-3-(1-methyl-2-oxocyclohexyl)-propionic acid methyl ester 

Downstream Products

• 477309-84-5 [3-allyl-6-methyl-9-(1-methyl-2-vinyl-cyclohex-2-enyl)-non-5-enyl]-benzylether 
• 429676-76-6 (S)-6-[3-(tert-butyldiphenylsilyloxy)-propyl]-6-methyl-1-vinyl-cyclohexene 
• 477309-63-0 (S)-6-(3-hydroxypropyl)-6-methyl-1-vinyl-cyclohexene 
• 429676-77-7 (S)-6-(3-iodopropyl)-6-methyl-1-vinyl-cyclohexene 
• 275825-03-1 (S)-6-methyl-6-(4-methylpent-4-en-1-yl)-1-vinylcyclohex-1-ene 

Relevant academic research and scientific papers

Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors

Biologically active natural products can be regarded as evolutionary selected and biologically validated starting points in structural space for the development of compound libraries. For libraries designed and synthesized around a given natural product,

Natural products are biologically validated starting points in structural space for compound library development: Solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

A multistep solid-phase synthesis was used successfully to prepare a series of analogues (see picture) of the protein phosphatase inhibitor dysidiolide. The natural product and its analogues were prepared on a solid support over 8 - 12 linear steps with o