429682-81-5Relevant academic research and scientific papers
Estrogen receptor β-subtype selective tetrahydrofluorenones: Use of a fused pyrazole as a phenol bioisostere
Wilkening,Ratcliffe,Fried,Meng,Sun,Colwell,Lambert,Greenlee,Nilsson,Thorsell,Mojena,Tudela,Frisch,Chan,Birzin,Rohrer,Hammond
, p. 3896 - 3901 (2006)
Synthesis of a series of fused pyrazole tetrahydrofluorenone analogs which are potent, ERβ subtype selective ligands is described. Analogs possessing subnanomolar ERβ binding, greater than 100-fold ERβ-selectivity, and oral bioavailability are reported.
