429685-00-7

Upstream product

• 383-70-0 TFA-Gly 
• 220438-32-4 (S)-(+)-methyl 2-<(trimethylsilyl)methyl>amino-3-phenylpropionate 
• 383-69-7 (2,2,2-trifluoro-acetylamino)-acetyl chloride 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 429685-01-8 (2S)-2-{methoxymethyl[2-(2,2,2-trifluoroacetylamino)acetyl]amino}-3-phenylpropionic acid methyl ester 

Relevant academic research and scientific papers

Building functionalized peptidomimetics: Use of electroauxiliaries for introducing N-acyliminium ions into peptides

A series of silyl-substituted amino acids have been synthesized, inserted into peptides, and then employed as precursors for oxidatively generating reactive N-acyliminium ions. Both electrochemical and chemical oxidation procedures have been employed. N-Acyliminium ion generation in a solid-phase substrate as well as application to a small library of functionalized dipeptides has been demonstrated. Limitations in terms of how electron-rich the silyl groups can be as well as the compatibility of multiple silyl groups within a longer peptide are defined.

Silyl-Substituted Amino Acids: New Routes to the Construction of Selectively Functionalized Peptidomimetics

(matrix presented) Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or exter