429692-36-4Relevant academic research and scientific papers
Activity-based fluorescent probes that target phosphatases
Zhu, Qing,Huang, Xuan,Chen, Grace Y. J.,Yao, Shao Q.
, p. 2669 - 2672 (2007/10/03)
We have successfully designed and synthesized two fluorescently-labeled, activity-based probes, Probe 1 and Probe 2, which were shown to label protein tyrosine phosphatases specifically, as well as other types of phosphatases. The probes were not reactive towards the other non-phosphatase enzymes tested. These probes may find potential applications in large-scale proteomic experiments whereby subclasses of proteins may be selectively identified.
