42972-13-4

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid is used as a key intermediate in the synthesis of novel compounds with potential medicinal benefits. Its unique chemical structure and reactivity contribute to the development of new drugs with improved therapeutic properties.
Used in Materials Science:
Due to its unique chemical structure, 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid may also have applications in materials science and other industrial fields, where its properties can be harnessed to create innovative materials with specific characteristics and functions.

InChI:InChI=1/C9H6N2O4/c12-7-5-2-1-4(9(14)15)3-6(5)8(13)11-10-7/h1-3H,(H,10,12)(H,11,13)(H,14,15)/p-1

Upstream product

• 552-30-7 trimellitic Anhydride 
• 528-44-9 1,2,4-benzene tricarboxylic acid 

Downstream Products

• 1028338-77-3 1,4-dichloro-phthalazine-6-carboxylic acid m-tolylamide 
• 1028338-38-6 1,4-dichloro-phthalazine-6-carboxylic acid phenylamide 
• 1028338-39-7 1,4-dichloro-phthalazine-6-carboxylic acid (3-methoxy-phenyl)-amide 
• 1028338-78-4 1,4-dichloro-phthalazine-6-carboxylic acid (3-trifluoromethoxy-phenyl)-amide 
• 1028338-73-9 1,4-dichloro-phthalazine-6-carboxylic acid (3-piperidin-1-ylmethyl-phenyl)-amide 
• 1028338-48-8 1,4-dichloro-phthalazine-6-carboxylic acid (4-trifluoromethylphenyl)amide 
• 1028338-36-4 1,4-dichloro-phthalazine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide 
• 1028338-66-0 1,4-dichloro-phthalazine-6-carboxylic acid (3-difluoromethoxy-phenyl)-amide 
• 1028338-76-2 1,4-dichloro-phthalazine-6-carboxylic acid (3-furan-2-yl-phenyl)-amid 
• 1028338-74-0 1,4-dichloro-phthalazine-6-carboxylic acid (2-morpholin-4-yl-5-trifluoromethyl-phenyl)-amide 

Relevant academic research and scientific papers

A series of coordination polymers constructed from in situ amidation ligands: Syntheses, structures and luminescent properties

From the hydrothermal in situ amidation reactions of aromatic polycarboxylates and hydrazine hydrate (N2H4·H 2O), four complexes, dinuclear [Cu(μ2-H 3bbch)(H2O)]2·2H2O (1), 3-D grid-like [Fe3(μ5-Hbbch)2(μ2- H2O)2(H2O)2]·2H2O (2), 2-D layer [Zn(μ2-H2bbh)(μ2-N 2H4)1/2(H2O)]·2H 2O (3) and 3-D supramolecular structure [Cd(H2bch) 2(2,2′-bpy)(H2O)2][Cd(μ2- H2bch)(2,2′-bpy)(H2O)2](H2bch) (4) have been prepared. The two different in situ amidated ligands in 1, 2 and 3, benzene-4,5-bicarboxylate-1,2-hydrazide (H4bbch) and benzene-1,2,4,5-bihydrazide (H4bbh), were formed through adjusting the ratios of pyromellitic acid (PMA) and N2H4· H2O, of which H4bbch was generated through hydrothermal in situ amidation reactions for the first time. Benzene-4-carboxylate-1,2- hydrazide (H3bch), displaying three new coordination modes in 4, was also an in situ amidation product of benzene-1,2,4-tricarboxylic acid (H 3btca) and N2H4·H2O. 1-4 were characterized by elemental analysis, infrared spectroscopy, and thermogravimetric analysis. Their structures were determined by single-crystal X-ray diffraction. The fluorescence properties of compounds 1, 3 and 4 were also investigated. The Royal Society of Chemistry 2012.

4-Carboxylphthalhydrazidate-bridged layered Pb(ii) coordination polymers

The hydrothermal in situ self-assembly of Pb2+, benzene-1,2,4-tricarboxylic acid (BTCA) and N2H4· H2O created two Pb(ii) coordination polymers containing 4-carboxylphthalhydrazidate (CPTH), [Pb(CPTH)(phen)] (phen = 1,10-phenanthroline) 1 and [Pb4(OH)2(H2O) 3(CPTH)3]·2H2O 2. CPTH is derived from the in situ acylation reaction of BTCA with N2H4· H2O. The Royal Society of Chemistry 2010.

Direct chemoselective synthesis of glyconanoparticles from unprotected reducing glycans and glycopeptide aldehydes

Chemoselective oxime coupling was used for facile conjugation of unprotected, reducing glycans and glycopeptide aldehydes with core?shell gold nanoparticles carrying reactive aminooxy groups on the organic shell.

PHTHALAZINE DERIVATIVES

The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Methods of inhibiting BTK and SYK protein kinases

Methods of inhibiting a tyrosine kinase wherein said tyrosine kinase is BTK or SYK comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to formula I are disclosed. The compounds are useful for treating auto-immune and inflammatory diseases.

NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.