42972-13-4

Basic information

• Product Name: 1,4-DIOXO-1,2,3,4-TETRAHYDROPHTHALAZINE-6-CARBOXYLIC ACID
• Synonyms: 6-phthalazinecarboxylic acid, 1,2,3,4-tetrahydro-1,4-dioxo;6-Phthalazinecarboxylicacid, 3,4-dihydro-1-hydroxy-4-oxo-;1,4-diketo-2,3-dihydrophthalazine-6-carboxylic acid;1,4-dioxo-2,3-dihydrophthalazine-6-carboxylic acid;A3993/0170153;NSC211205;Ammonium (1,4-dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid)acetate
• CAS NO: 42972-13-4
• Molecular Formula: C₉H₆N₂O₄
• Molecular Weight: 206.15
• Mol File: 42972-13-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.540±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.50±0.20(Predicted)
• CAS DataBase Reference: 1,4-DIOXO-1,2,3,4-TETRAHYDROPHTHALAZINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIOXO-1,2,3,4-TETRAHYDROPHTHALAZINE-6-CARBOXYLIC ACID(42972-13-4)
• EPA Substance Registry System: 1,4-DIOXO-1,2,3,4-TETRAHYDROPHTHALAZINE-6-CARBOXYLIC ACID(42972-13-4)

Safety Data

• Hazardous Substances Data: 42972-13-4(Hazardous Substances Data)

Usage

General Description

1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid is a chemical compound with the molecular formula C9H7NO5. It is a heterocyclic compound containing a six-membered ring with two oxygen atoms and a carboxylic acid group. This chemical is used in pharmaceutical research and drug development due to its potential biological activities and therapeutic applications. Its structure and properties make it a valuable candidate for the synthesis of novel compounds with potential medicinal benefits. Additionally, it may also have applications in materials science and other industrial fields due to its unique chemical structure and reactivity.

InChI:InChI=1/C9H6N2O4/c12-7-5-2-1-4(9(14)15)3-6(5)8(13)11-10-7/h1-3H,(H,10,12)(H,11,13)(H,14,15)/p-1

Upstream product

• 528-44-9 1,2,4-benzene tricarboxylic acid 
• 552-30-7 trimellitic Anhydride 

Downstream Products

• 1028338-77-3 1,4-dichloro-phthalazine-6-carboxylic acid m-tolylamide 
• 1028338-38-6 1,4-dichloro-phthalazine-6-carboxylic acid phenylamide 
• 1028338-39-7 1,4-dichloro-phthalazine-6-carboxylic acid (3-methoxy-phenyl)-amide 
• 1028338-78-4 1,4-dichloro-phthalazine-6-carboxylic acid (3-trifluoromethoxy-phenyl)-amide 
• 1028338-73-9 1,4-dichloro-phthalazine-6-carboxylic acid (3-piperidin-1-ylmethyl-phenyl)-amide 
• 1028338-48-8 1,4-dichloro-phthalazine-6-carboxylic acid (4-trifluoromethylphenyl)amide 
• 1028338-36-4 1,4-dichloro-phthalazine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide 
• 1028338-66-0 1,4-dichloro-phthalazine-6-carboxylic acid (3-difluoromethoxy-phenyl)-amide 
• 1028338-76-2 1,4-dichloro-phthalazine-6-carboxylic acid (3-furan-2-yl-phenyl)-amid 
• 1028338-74-0 1,4-dichloro-phthalazine-6-carboxylic acid (2-morpholin-4-yl-5-trifluoromethyl-phenyl)-amide 

Relevant articles and documents

A series of coordination polymers constructed from in situ amidation ligands: Syntheses, structures and luminescent properties

From the hydrothermal in situ amidation reactions of aromatic polycarboxylates and hydrazine hydrate (N2H4·H 2O), four complexes, dinuclear [Cu(μ2-H 3bbch)(H2O)]2·2H2O (1), 3-D grid-like [Fe3(μ5-Hbbch)2(μ2- H2O)2(H2O)2]·2H2O (2), 2-D layer [Zn(μ2-H2bbh)(μ2-N 2H4)1/2(H2O)]·2H 2O (3) and 3-D supramolecular structure [Cd(H2bch) 2(2,2′-bpy)(H2O)2][Cd(μ2- H2bch)(2,2′-bpy)(H2O)2](H2bch) (4) have been prepared. The two different in situ amidated ligands in 1, 2 and 3, benzene-4,5-bicarboxylate-1,2-hydrazide (H4bbch) and benzene-1,2,4,5-bihydrazide (H4bbh), were formed through adjusting the ratios of pyromellitic acid (PMA) and N2H4· H2O, of which H4bbch was generated through hydrothermal in situ amidation reactions for the first time. Benzene-4-carboxylate-1,2- hydrazide (H3bch), displaying three new coordination modes in 4, was also an in situ amidation product of benzene-1,2,4-tricarboxylic acid (H 3btca) and N2H4·H2O. 1-4 were characterized by elemental analysis, infrared spectroscopy, and thermogravimetric analysis. Their structures were determined by single-crystal X-ray diffraction. The fluorescence properties of compounds 1, 3 and 4 were also investigated. The Royal Society of Chemistry 2012.

Direct chemoselective synthesis of glyconanoparticles from unprotected reducing glycans and glycopeptide aldehydes

Chemoselective oxime coupling was used for facile conjugation of unprotected, reducing glycans and glycopeptide aldehydes with core?shell gold nanoparticles carrying reactive aminooxy groups on the organic shell.

Methods of inhibiting BTK and SYK protein kinases

Methods of inhibiting a tyrosine kinase wherein said tyrosine kinase is BTK or SYK comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to formula I are disclosed. The compounds are useful for treating auto-immune and inflammatory diseases.