4299-13-2

Basic information

• Product Name: 2-(2-hydroxypropyl)-1,2-benzothiazol-3(2H)-one
• CAS NO: 4299-13-2
• Molecular Formula: C₁₀H₁₁NO₂S
• Molecular Weight: 209.2648
• Mol File: 4299-13-2.mol

Chemical Properties

• Boiling Point: 384.5°C at 760 mmHg
• Flash Point: 186.4°C
• Density: 1.328g/cm³
• Vapor Pressure: 1.34E-06mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 2-(2-hydroxypropyl)-1,2-benzothiazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-hydroxypropyl)-1,2-benzothiazol-3(2H)-one(4299-13-2)
• EPA Substance Registry System: 2-(2-hydroxypropyl)-1,2-benzothiazol-3(2H)-one(4299-13-2)

Safety Data

• Hazardous Substances Data: 4299-13-2(Hazardous Substances Data)

Usage

Structure

Benzothiazole derivative with a hydroxypropyl group attached to the nitrogen atom

Usage

Production of industrial chemicals, additives for the rubber industry

Potential applications

Antioxidant, antimicrobial properties

Pharmaceutical applications

Inhibitor of enzymes involved in disease processes

Upstream product

• 73845-37-1 2,2'-dithiobis- 
• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 78-96-6 3-amino-2-propanol 

Relevant articles and documents

Antimicrobial activity of N-hydroxyalkyl 1,2-benzisothiazol-3(2H)-ones and their thiono analogues

N-Hydroxyalkyl derivatives of 1,2-benzisothiazol-3(2H)-one and 1,2-benzisothiazol-3(2H)-thione have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were active against selected fungi and Gram-positive microorganisms. Interesting activity was observed against the anaerobic strain Clostridium perfringens. Generally the more active compounds belong to the class of 1,2-benzisothiazol-3(2H)-ones. The retardation matches R(M) of the compounds was also evaluated but the results obtained show that lipophilicity has only a minor effect on the antimicrobial activity.

Synthesis and Antibacterial Activity of 2,2'-Dithiobis(benzamide) Derivatives against Mycobacterium Species

A series of compounds, which are analogues of 2,2'-dithiobis(benzamide), were synthesized and tested for in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide.MICs of these compounds against a typical mycobacteria, Mycobacterium kansasii and Mycobacteruim intracellulare were also examined.Structure-activity relationships were found in a series of (acyloxy)alkyl ester derivatives depending upon the length of alkyl carbon chain.The MIC of the most potent compound , 2,2'-dithiobisbenzamide> was superior or at least equivalent to streptomycin, kanamycin, and ethanbutol.All the compounds showed no cross-resistance between the current antitubercular agents.