42990-75-0Relevant academic research and scientific papers
METAL COMPLEXES OF TETRAAZAMACROCYCLE DERIVATIVES
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Page/Page column 15, (2008/06/13)
Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof.
CONTRAST AGENTS ENDOWED WITH HIGH RELAXIVITY
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Page/Page column 85-86, (2008/06/13)
The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhdroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.
Modified Di- and Tripeptides of the C-Terminal Portion of Oxytocin and Vasopressin as Possible Cognition Activation Agents
Nicolaides, E. D.,Tinney, F. J.,Kaltenbronn, J. S.,Repine, J. T.,DeJohn, D. A.,et al.
, p. 959 - 971 (2007/10/02)
A number of peptides and modified peptides were synthesized and studied for their ability to reverse electroconvulsive shock-induced amnesia in rodents.A few of these peptides were selected for secondary evaluation in tests of short-term memory in rats and aged rhesus monkeys.A number of the peptides and modified peptides were active in the amnesia reversal test.In selected secondary tests, however, the chosen compounds failed to show significant activity in enhancing memory.New methods for preparing methyleneamino and methyleneoxy isosters of peptides are reportrd.Other modified peptides also included methylenethio, methylenesulfonyl, and ethylene isosteres in place of the normal peptide amide bond.
