42998-67-4Relevant academic research and scientific papers
Structural characterization of N,NBis(diphenylphosphanyl)propylamine
Mayer, Tobias,Boettcher, Hans-Christian
, p. 504 - 506 (2012)
The synthesis and structural characterization of the Nsubstituted bis(diphenylphosphanyl)amine Ph2PN(R)PPh2 (R = n-propyl, 1) is reported. Single crystals of 1 grown from dichloromethane/acetonitrile have been analyzed by Xray crystallography. The crystal
Phosphino-amine (PN) Ligands for Rapid Catalyst Discovery in Ruthenium-Catalyzed Hydrogen-Borrowing Alkylation of Anilines: A Proof of Principle
Broomfield, Lewis Marc,Wu, Yichen,Martin, Eddy,Shafir, Alexandr
supporting information, p. 3538 - 3548 (2016/01/25)
A general synthetic protocol for the synthesis of simple phosphino-amine (PN) ligands is described with 19 ligands being isolated in good yields. High-throughput ligand screening uncovered the success of two of these ligands for aromatic amine alkylations via ruthenium-catalyzed hydrogen borrowing reactions. The combination of N,N'-bis(diphenylphosphino)-N,N′-dimethylpropylenediamine with a ruthenium(II) source and potassium hydroxide (15 mol%) is the optimal system for selective monobenzylations of aromatic amines (method A). Over 70% isolated yields have been achieved for the formation of 14 secondary aromatic amines under mild reaction conditions (120 C and 1.05 equivalents of benzyl alcohol). On the other hand, N,N-bis(diphenylphosphino)-isopropylamine was the ligand utilized for both selective monomethylation and monoethylation reactions of aromatic amines (method B). Here the alcohol is charged as both the reaction medium and substrate and 9 examples are disclosed with all isolated yields exceeding 70%. These methods have been applied to the synthesis of important synthetic building blocks based on aminoferrocene.
