43010-05-5Relevant academic research and scientific papers
Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs
-
, (2008/06/13)
Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti--inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.
Analogues of 8-amino>-6-methoxy-4-methylquinoline as Candidate Antileishmanial Agents
LaMontagne, Maurice P.,Dagli, Dinesh,Khan, M. Sami,Blumbergs, Peter
, p. 981 - 985 (2007/10/02)
8-amino>-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate.Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds.The compounds were tested against L. donovani in the golden hamster.Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.
