4302-54-9

Usage

Uses

Used in Flavor and Fragrance Industry:
ETHYL 2-METHYL-5-(4-METHYLPHENYL)-3-FUROATE is used as a flavor or fragrance ingredient for its sweet, fruity, and slightly floral odor. It is commonly found in various consumer products such as perfumes, colognes, and food flavorings.
Used in Pharmaceutical Industry:
Additionally, ETHYL 2-METHYL-5-(4-METHYLPHENYL)-3-FUROATE is used in the production of pharmaceuticals, where it may contribute to the scent or serve as a chemical intermediate in the synthesis of other compounds.
Used in Organic Synthesis:
ETHYL 2-METHYL-5-(4-METHYLPHENYL)-3-FUROATE also serves as a chemical intermediate in organic synthesis, playing a crucial role in the development of new chemical compounds and materials.

InChI:InChI=1/C15H16O3/c1-4-17-15(16)13-9-14(18-11(13)3)12-7-5-10(2)6-8-12/h5-9H,4H2,1-3H3

Upstream product

• 111787-81-6 ethyl 2-acetyl-4-oxo-4-(p-tolyl)butanoate 
• 141-97-9 ethyl acetoacetate 
• 619-41-0 4-(bromoacetyl)toluene 
• 766-97-2 4-n-methylphenylacetylene 
• 60672-33-5 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide 
• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 

Downstream Products

• 111787-86-1 2-methyl-5-(4-methylphenyl)-3-furoic acid 
• 4302-56-1 (2-methyl-5-p-tolyl-furan-3-yl)-methanol 

Relevant academic research and scientific papers

Synthesis of polysubstituted furans from aryl gem-dibromoethenes

[Figure not available: see fulltext.] Synthesis of 2,3,5-trisubstituted furans can be performed at 120°C in DMF using aryl gem-dibromoethenes and ethyl acetoacetate as the starting substrates under the assistance of Ag2CO3–Cs2/

Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans

The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate to good yields. The features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. The studies provide important approaches for further exploration of the powerful and diverse reaction abilities of N-tosylhydrazones.

Tuning radical reactivity using iodine in oxidative C(sp3)-H/C(sp)-H cross-coupling: An easy way toward the synthesis of furans and indolizines

Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for co

Silver-mediated oxidative C-H/C-H functionalization: A strategy to construct polysubstituted furans

A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver specie

One-pot synthesis of furans using base- and acid-supported reagents Na 2CO3/Al2O3-PPA/SiO2'

A convenient method for the one-pot synthesis of furans from -keto esters and -halo ketones was developed using an acid- and base-supported reagent system Na2CO3/Al2O3-PPA/SiO2'. The condensation reaction of triketones, which are formed from the reaction of -keto esters with -halo ketones in the presence of Na2CO 3/Al2O3, was promoted by PPA/SiO2 to give the corresponding furans in good yields. This method is simple and easy to perform in comparison with stepwise processes, and the yields are good.